TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia.
Adrenaline Secretion
Calcium Signaling
Chromaffin Cells
Hypoglycemia Associated Autonomic Failure
TRPC5 Channels
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
07 Oct 2024
07 Oct 2024
Historique:
received:
14
06
2024
accepted:
12
08
2024
revised:
10
07
2024
medline:
8
10
2024
pubmed:
8
10
2024
entrez:
7
10
2024
Statut:
aheadofprint
Résumé
Hypoglycemia triggers autonomic and endocrine counter-regulatory responses to restore glucose homeostasis, a response that is impaired in patients with diabetes and its long-term complication hypoglycemia-associated autonomic failure (HAAF). We show that insulin-evoked hypoglycemia is severely aggravated in mice lacking the cation channel proteins TRPC1, TRPC4, TRPC5, and TRPC6, which cannot be explained by alterations in glucagon or glucocorticoid action. By using various TRPC compound knockout mouse lines, we pinpointed the failure in sympathetic counter-regulation to the lack of the TRPC5 channel subtype in adrenal chromaffin cells, which prevents proper adrenaline rise in blood plasma. Using electrophysiological analyses, we delineate a previously unknown signaling pathway in which stimulation of PAC1 or muscarinic receptors activates TRPC5 channels in a phospholipase-C-dependent manner to induce sustained adrenaline secretion as a crucial step in the sympathetic counter response to insulin-induced hypoglycemia. By comparing metabolites in the plasma, we identified reduced taurine levels after hypoglycemia induction as a commonality in TRPC5-deficient mice and HAAF patients.
Identifiants
pubmed: 39375537
doi: 10.1038/s44318-024-00231-0
pii: 10.1038/s44318-024-00231-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : TR-SFB 152
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : SFB 1118
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : SFB 1550
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : CRC 894
Organisme : Universität des Saarlandes (Saarland University)
ID : Young Investigator Grant
Informations de copyright
© 2024. The Author(s).
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