Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant.

DPYD gene polymorphism capecitabine case report pheno- and genotyping rare variant

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2024
Historique:
received: 04 07 2024
accepted: 09 09 2024
medline: 8 10 2024
pubmed: 8 10 2024
entrez: 8 10 2024
Statut: epublish

Résumé

Variations in the activity of the enzyme dihydropyrimidine dehydrogenase (DPD) are associated with toxicity to fluoropyrimidine-containing chemotherapy. Testing of DPD deficiency either by targeted genotyping of the corresponding

Identifiants

DOI: 10.3389/fphar.2024.1459565 PMID: 39376610 PMC: PMC11456491
pubmed: 39376610
doi: 10.3389/fphar.2024.1459565
pii: 1459565
pmc: PMC11456491
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Pagination

1459565

Informations de copyright

Copyright © 2024 de Haar-Holleman, Cortoos, Vlaeminck, Van Landuyt, Steurbaut, Vaeyens and Haufroid.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Amy de Haar-Holleman (A)

Department of Medical Oncology, Universitair Ziekenhuis Brussel (UZBrussel), Brussels, Belgium.
Translational Oncology Research Center (TORC), Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Pieter-Jan Cortoos (PJ)

Pharmacy Department, Universitair Ziekenhuis Brussel (UZBrussel), Brussels, Belgium.
Faculty of Medicine & Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Jelle Vlaeminck (J)

Centre for Medical Genetics, Research Group Genetics, Reproduction and Development, Clinical Sciences, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

Paulien Van Landuyt (P)

Pharmacy Department, Universitair Ziekenhuis Brussel (UZBrussel), Brussels, Belgium.

Stephane Steurbaut (S)

Pharmacy Department, Universitair Ziekenhuis Brussel (UZBrussel), Brussels, Belgium.
Faculty of Medicine & Pharmacy, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Freya Vaeyens (F)

Centre for Medical Genetics, Research Group Genetics, Reproduction and Development, Clinical Sciences, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

Vincent Haufroid (V)

Louvain Center for Toxicology and Applied Pharmacology, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCLouvain), Brussels, Belgium.
Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Classifications MeSH