A GWAS for grip strength in cohorts of children-Advantages of analysing young participants for this trait.
ALSPAC
GWAS
Raine study
complex traits
grip strength
neurodevelopment
Journal
Genes, brain, and behavior
ISSN: 1601-183X
Titre abrégé: Genes Brain Behav
Pays: England
ID NLM: 101129617
Informations de publication
Date de publication:
Oct 2024
Oct 2024
Historique:
revised:
02
09
2024
received:
28
02
2024
accepted:
10
09
2024
medline:
8
10
2024
pubmed:
8
10
2024
entrez:
8
10
2024
Statut:
ppublish
Résumé
Grip strength (GS) is a proxy measure for muscular strength and a predictor for bone fracture risk among other diseases. Previous genome-wide association studies (GWASs) have been conducted in large cohorts of adults focusing on scores collected for the dominant hand, therefore increasing the likelihood of confounding effects by environmental factors. Here, we perform the first GWAS meta-analyses on maximal GS with the dominant (GSD) and non-dominant (GSND) hand in two cohorts of children (ALSPAC, N = 5450; age range = 10.65-13.61; Raine Study, N = 1162, age range: 9.42-12.38 years). We identified a novel significant association for GSND (rs9546244, LINC02465, p = 3.43e-08) and replicated associations previously reported in adults including with a HOXB3 gene marker that shows an expression quantitative trait locus (eQTL) effect. Despite a much smaller sample (~3%) compared with the UK Biobank we replicated correlation analyses previously reported in this much larger adult cohort, such as a negative correlation with coronary artery disease. Although the results from the polygenic risk score (PRS) analyses did not survive multiple testing correction, we observed nominally significant associations between GS and risk of overall fracture, as previously reported, as well ADHD which will require further investigations. Finally, we observed a higher SNP-heritability (24%-41%) compared with previous studies (4%-24%) in adults. Overall, our results suggest that cohorts of children might be better suited for genetic studies of grip strength, possibly due to the shorter exposure to confounding environmental factors compared with adults.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e70003Subventions
Organisme : Royal Society
ID : RGF\EA\180141
Organisme : Royal Society
ID : UF150663
Organisme : Medical Research Scotland
ID : PhD-50010-2019
Organisme : Medical Research Council
ID : 102215/2/13/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 105621/Z/14/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204821/Z/16/Z
Pays : United Kingdom
Organisme : National Health and Medical Research Council of Australia (NHMRC)
ID : 1059711
Organisme : National Health and Medical Research Council of Australia (NHMRC)
ID : 403981
Organisme : National Health and Medical Research Council of Australia (NHMRC)
ID : 572613
Organisme : Deutsche Forschungsgemeinschaft
ID : 418445085
Informations de copyright
© 2024 The Author(s). Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.
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