Treatment strategy for cervical lymph node metastases from early-stage tongue and floor of the mouth squamous cell carcinoma using tumour budding and depth of invasion as predictors.
Humans
Male
Female
Lymphatic Metastasis
/ pathology
Middle Aged
Carcinoma, Squamous Cell
/ pathology
Neoplasm Invasiveness
Tongue Neoplasms
/ pathology
Aged
Neoplasm Staging
Adult
Prognosis
Neck Dissection
Mouth Floor
/ pathology
Mouth Neoplasms
/ pathology
Risk Factors
Biopsy
Aged, 80 and over
Retrospective Studies
Biopsy
Cervical lymph node metastasis
Depth of invasion
Early tongue and floor of the mouth squamous cell carcinoma
Tumour budding
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
received:
30
07
2024
accepted:
29
09
2024
medline:
9
10
2024
pubmed:
9
10
2024
entrez:
8
10
2024
Statut:
epublish
Résumé
This study aimed to determine whether elective neck dissection can help improve outcomes in early-stage tongue and floor squamous cell carcinoma (SCC) by statistically analysing the relationship between information obtained from biopsy specimens and the incidence and prognosis of cervical lymph node metastasis (CLM). Biopsy specimens of 103 patients diagnosed with early cT1-T2 cancer of the tongue and floor of the mouth were included. Multivariate analysis showed that the three parameters significantly correlated with CLM, and univariate analyses showed that budding score (BS) ≥ 5 and pathological depth of invasion (pDOI) ≥ 5 mm were independent risk factors for CLM. There were significant differences in the 5-year cumulative disease-specific survival between the BS < 5 and BS ≥ 5 groups, the pDOI < 5 mm and pDOI ≥ 5 mm groups, and the positive and negative budding and depth of invasion (BD) score groups. In early-stage tongue and floor of the mouth cancers with maximum tumour diameter ≤ 20 mm, it may be necessary to treat occult CLM during initial surgery based on the following preoperative criteria: pDOI ≥ 5 mm or BS ≥ 5 in biopsy specimens and DOI ≥ 8 mm on imaging. The BD model exhibited the highest specificity and proved helpful for CLM prediction. pDOI ≥ 5 mm and BS ≥ 5 were independent predictors of CLM and prognosis in early-stage tongue and floor of the mouth cancers with a maximum tumour diameter of 20 mm.
Identifiants
pubmed: 39379623
doi: 10.1007/s00784-024-05974-y
pii: 10.1007/s00784-024-05974-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
580Informations de copyright
© 2024. The Author(s).
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