Bone Marrow Adiposity Alterations in Postmenopausal Women With Type 2 Diabetes Are Site-Specific.

Bone marrow adiposity (BMAT) alterations in patients with type 2 diabetes mellitus (T2DM) may contribute to adverse bone effects. Characterization of BMAT content and composition in patients with well-controlled T2DM. This cross-sectional study included 2 groups of postmenopausal women: one with T2DM and the other without. The proton density fat fraction (PDFF) of the lumbar spine and proximal femur, comprising the femoral head, neck, and diaphysis, was assessed using chemical shift-based water-fat separation imaging (WFI). Magnetic resonance imaging with spectroscopy ( Among 199 participants, patients with T2DM (n = 29) were significantly heavier ( The content and composition of BMAT are modified in postmenopausal women with T2DM and these changes occur at specific sites.

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.