Therapeutic potential of Astragalus membranaceus-Pueraria lobata decoction for the treatment of chemotherapy bowel injury.
Astragalus membranaceus
Drosophila melanogaster
Pueraria lobata decoction
chemotherapy
intestinal mucositis
molecular mechanism
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
15 Oct 2024
15 Oct 2024
Historique:
revised:
05
09
2024
received:
21
07
2024
accepted:
30
09
2024
medline:
9
10
2024
pubmed:
9
10
2024
entrez:
9
10
2024
Statut:
ppublish
Résumé
Intestinal mucositis (IM) is one of the most serious side effects of the chemotherapeutic agent irinotecan (CPT-11). Astragalus membranaceus-Pueraria lobata decoction is from the ancient medical book Zhengzhihuibu, has been reported to be used for the treatment of diabetes and hypertension. However, the beneficial effect and mechanism of AP on chemotherapy intestinal mucositis (CIM) remain largely unknown. This study aimed to investigate the efficacy and mechanism of Astragalus membranaceus-Pueraria lobata decoction (AP) in treating CIM. The beneficial effect and mechanism of AP on chemotherapy intestinal mucositis (CIM) were detected using Drosophila model, and combination with RT qPCR, transcriptomics. AP supplementation could significantly alleviate the CPT-11-induced body injury in Drosophila, such as increasing the survival rate, recovering the impaired digestion, improving the movement, and repairing the reproduction and developmental processes. Administration of AP remarkably alleviated the IM caused by CPT-11, including inhibiting the excretion, repairing the intestinal atrophy, improving the acid-base homeostasis imbalance, and inhibiting the disruption of intestinal structure. Mechanistic studies revealed that the protective role of AP against CPT-11 induced intestinal injury was regulated mainly by inhibiting immune-related Toll and Imd pathways, and enhancing the antioxidant capacity. Taken together, these results suggest that AP may be a novel agent to relieve CIM.
Identifiants
pubmed: 39382026
doi: 10.1096/fj.202401677R
doi:
Substances chimiques
Irinotecan
7673326042
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e70102Subventions
Organisme : Gansu Natural Science Foundation
ID : 23JRRA1202
Organisme : National Natural Science Foundation of China (NSFC)
ID : 82104562
Organisme : National Natural Science Foundation of China (NSFC)
ID : 82360896
Organisme : Gansu Provincial Department of Education Innovation Ability Enhancement Project
ID : 2023A-086
Organisme : Gansu Provincial Department of Education
ID : 2023CXZX-769
Informations de copyright
© 2024 Federation of American Societies for Experimental Biology.
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