Modifiable dementia risk factors associated with objective and subjective cognition.
age interactions
cognitive flexibility
cognitive impairment
cross‐sectional study
depression
executive function
model‐based planning
modifiable risk factors for dementia
smartphone assessment
smartphone data collection
subjective cognitive complaints
subjective memory problems
visual working memory
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
revised:
28
03
2024
received:
15
11
2023
accepted:
19
04
2024
medline:
9
10
2024
pubmed:
9
10
2024
entrez:
9
10
2024
Statut:
aheadofprint
Résumé
Early detection of both objective and subjective cognitive impairment is important. Subjective complaints in healthy individuals can precede objective deficits. However, the differential associations of objective and subjective cognition with modifiable dementia risk factors are unclear. We gathered a large cross-sectional sample (N = 3327, age 18 to 84) via a smartphone app and quantified the associations of 13 risk factors with subjective memory problems and three objective measures of executive function (visual working memory, cognitive flexibility, model-based planning). Depression, socioeconomic status, hearing handicap, loneliness, education, smoking, tinnitus, little exercise, small social network, stroke, diabetes, and hypertension were all associated with impairments in at least one cognitive measure. Subjective memory had the strongest link to most factors; these associations persisted after controlling for depression. Age mostly did not moderate these associations. Subjective cognition was more sensitive to self-report risk factors than objective cognition. Smartphones could facilitate detecting the earliest cognitive impairments. Smartphone assessments of cognition were sensitive to dementia risk factors. Subjective cognition had stronger links to most factors than did objective cognition. These associations were not fully explained by depression. These associations were largely consistent across the lifespan.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Global Brain Health Institute
ID : 18GPA02
Organisme : Science Foundation Ireland
ID : 19/FFP/6418
Pays : Ireland
Organisme : Irish Research Council
ID : GOIPD/2023/1238
Organisme : ANID/FONDECYT Regular
ID : 1210195
Organisme : ANID/FONDECYT Regular
ID : 1210176
Organisme : ANID/FONDECYT Regular
ID : 1220995
Organisme : ANID/PIA/ANILLOS
ID : ACT210096
Organisme : ANID/FONDAP
ID : 15150012
Organisme : FIC NIH HHS
Pays : United States
Organisme : NIH HHS
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057234
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG075775
Pays : United States
Organisme : National Institutes of Aging
ID : R01 AG21051
Organisme : Alzheimer's Association
ID : SG-20-725707
Pays : United States
Organisme : Rainwater Charitable Foundation - Tau Consortium
Organisme : The Bluefield Project to Cure Frontotemporal Dementia
Organisme : Global Brain Health Institute, Alzheimer's Association, and Alzheimer's Society
ID : GBHIALZUK-24-1068607
Informations de copyright
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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