A review of therapies for hyperpigmentation modulating the synthesis of eumelanin to pheomelanin.
Cysteamine
Eumelanin
Glutathione
Kojic acid
Methyl sulfonyl methane
Pheomelanin
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
received:
12
08
2024
accepted:
17
09
2024
revised:
06
09
2024
medline:
9
10
2024
pubmed:
9
10
2024
entrez:
9
10
2024
Statut:
epublish
Résumé
There are significant psychosocial burdens in patients with hyperpigmentation, which emphasizes the importance of treatment. Current gold standard for treatment is hydroquinone; however, alternatives have been developed given the concern for side effects of hydroquinone. Melanogenesis is responsible for the production of eumelanin and pheomelanin; there are many factors that will determine whether eumelanin or pheomelanin will be produced. Eumelanin is known for its photoprotective qualities, while pheomelanin is implicated in photocarcinogenesis and photoaging. Multiple treatment modalities for hyperpigmentation that shift eumelanin to pheomelanin synthesis exist. Cysteamine, glutathione, kojic acid, and methyl sulfonyl methane are four agents used to treat hyperpigmentation by shifting the production of eumelanin to pheomelanin. It is critical to discuss photoprotection with patients to help reduce the potential impact of increased pheomelanin production and to expand research in this area.
Identifiants
pubmed: 39382722
doi: 10.1007/s00403-024-03411-4
pii: 10.1007/s00403-024-03411-4
doi:
Substances chimiques
Melanins
0
pheomelanin
0
eumelanin
12627-86-0
kojic acid
6K23F1TT52
Pyrones
0
Glutathione
GAN16C9B8O
Hydroquinones
0
hydroquinone
XV74C1N1AE
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
668Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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