Enhanced alveolar ridge preservation with hyaluronic acid-enriched allografts: a comparative study of granular allografts with and without hyaluronic acid addition.
Humans
Hyaluronic Acid
/ therapeutic use
Retrospective Studies
Female
Male
Middle Aged
Allografts
/ drug effects
Adult
Alveolar Ridge Augmentation
/ methods
Bone Substitutes
/ pharmacology
Tooth Socket
/ surgery
Bone Transplantation
/ methods
Tooth Extraction
/ adverse effects
Aged
Alveolar Bone Loss
/ prevention & control
Bone Density
/ drug effects
Allogeneic bone material
Dental implants
Extraction sockets
Hyaluronic acid
Regenerative dentistry
Socket preservation
maxgraft®
Journal
International journal of implant dentistry
ISSN: 2198-4034
Titre abrégé: Int J Implant Dent
Pays: Germany
ID NLM: 101676532
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
received:
16
08
2024
accepted:
01
10
2024
medline:
9
10
2024
pubmed:
9
10
2024
entrez:
9
10
2024
Statut:
epublish
Résumé
Ridge preservation is essential to restore alveolar ridge volume and to enhance esthetic and functional outcomes for dental implants. The addition of hyaluronic acid to allogeneic bone substitute materials might enhance these outcomes. This clinical study evaluated the efficacy of ridge preservation after tooth extraction using granular allografts with and without hyaluronic acid addition. In this retrospective study, 40 patients with compromised extraction sockets were enrolled. Among them, 19 received particulate allogeneic bone substitutes (Allo), 21 received allogeneic bone substitutes with hyaluronic acid (AlloHya). Vertical and horizontal graft stability, graft shrinkage rate, and bone mineral density were assessed using radiographic measurements on CBCT scans conducted before tooth extraction, directly after ridge preservation and after four months. Patients were followed up 12 months post-implantation. Vertical height loss after 4 months was significantly greater in the Allo group (-0.82 ± 0.95 mm) compared to the AlloHya group (-0.19 ± 0.51 mm; p = 0.011). Graft shrinkage rate was 16.9 ± 11.5% (Allo) and 10.3 ± 7.7% (AlloHya) (p = 0.038). After four months, average bone density was significantly higher in the AlloHya compared to the Allo group (p = 0.004). Nearly all implants (39 out of 40) were classified as "Success" according to the ICOI scheme, with no differences in implant quality between the two study groups. Improved graft stability, reduced resorption, and increased bone density were observed in hyaluronic acid-enriched allografts compared to pure allografts. Adding hyaluronic acid to allogeneic bone grafts significantly enhanced outcomes in ridge preservation.
Identifiants
pubmed: 39382763
doi: 10.1186/s40729-024-00559-6
pii: 10.1186/s40729-024-00559-6
doi:
Substances chimiques
Hyaluronic Acid
9004-61-9
Bone Substitutes
0
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
42Informations de copyright
© 2024. The Author(s).
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