Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection.

Chiroptera / virology Animals Antibodies, Neutralizing / immunology Orthomyxoviridae Infections / immunology Antibodies, Viral / immunology Influenza A virus / immunology Virus Shedding / immunology
Jamaican fruit bats bat flu bat influenza A virus H18N11 humoral immune response neutralizing antibodies

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
15 Oct 2024
Historique:
medline: 9 10 2024
pubmed: 9 10 2024
entrez: 9 10 2024
Statut: ppublish

Résumé

Antibodies are an essential component of the antiviral response in many species, but to date, there is no compelling evidence that bats are capable of eliciting a robust humoral immunity, including neutralizing antibodies. Here, we report that infection of Jamaican fruit bats with the bat influenza A virus H18N11 elicits a rapid and stable humoral immune response with a strong neutralizing capacity, associated with no detectable viral shedding after repeat challenge infection. Thus, the neutralizing antibody response of bats might play an important role in the bat immunity.

Identifiants

DOI: 10.1073/pnas.2413619121 PMID: 39382992
pubmed: 39382992
doi: 10.1073/pnas.2413619121
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2413619121

Subventions

Organisme : EC | European Research Council (ERC)
ID : 882631
Organisme : NIAID NIH HHS
ID : R01 AI140442
Pays : United States
Organisme : Hans A. Krebs Medical Scientist Programme
ID : na

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Susanne Kessler (S)

Institute of Virology, Medical Center University of Freiburg, Freiburg 79104, Germany.
Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.
ORCID: 0000-0002-9720-8291

Philipp Stegen (P)

Institute of Virology, Medical Center University of Freiburg, Freiburg 79104, Germany.
Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.
ORCID: 0009-0004-0500-9917

Shijun Zhan (S)

Department of Microbiology, Immunology and Pathology, Center for Vector-borne Infectious Diseases, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.

Martin Schwemmle (M)

Institute of Virology, Medical Center University of Freiburg, Freiburg 79104, Germany.
Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.
ORCID: 0000-0002-2972-6855

Peter Reuther (P)

Institute of Virology, Medical Center University of Freiburg, Freiburg 79104, Germany.
Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.

Tony Schountz (T)

Department of Microbiology, Immunology and Pathology, Center for Vector-borne Infectious Diseases, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.

Kevin Ciminski (K)

Institute of Virology, Medical Center University of Freiburg, Freiburg 79104, Germany.
Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.
Department of Microbiology, Immunology and Pathology, Center for Vector-borne Infectious Diseases, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
ORCID: 0000-0001-5397-7497

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Chiroptera › Jamaican fruit bats mount a stable and highly...
questionsmedicales.fr › Eucaryotes › Animaux › Jamaican fruit bats mount a stable and highly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Jamaican fruit bats mount a stable and highly...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Orthomyxoviridae › Jamaican fruit bats mount a stable and highly...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Jamaican fruit bats mount a stable and highly...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Jamaican fruit bats mount a stable and highly...
questionsmedicales.fr › Phénomènes physiologiques › Excrétion virale › Jamaican fruit bats mount a stable and highly...