Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy.

Cell Transdifferentiation / genetics Humans Esophageal Neoplasms / genetics Animals Esophagus / metabolism Epigenesis, Genetic Mice Tumor Suppressor Proteins / metabolism Gene Expression Regulation, Neoplastic Trans-Activators / metabolism Cell Line, Tumor Carcinoma, Neuroendocrine / metabolism Enhancer of Zeste Homolog 2 Protein / metabolism Transcription Factors / metabolism Neuroendocrine Cells / metabolism

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
11 Oct 2024
Historique:
medline: 9 10 2024
pubmed: 9 10 2024
entrez: 9 10 2024
Statut: ppublish

Résumé

While cell fate determination and maintenance are important in establishing and preserving tissue identity and function during development, aberrant cell fate transition leads to cancer cell heterogeneity and resistance to treatment. Here, we report an unexpected role for the transcription factor p63 (Trp63/TP63) in the fate choice of the squamous versus neuroendocrine lineage in esophageal development and malignancy. Deletion of

Identifiants

DOI: 10.1126/sciadv.adq0479 PMID: 39383220
pubmed: 39383220
doi: 10.1126/sciadv.adq0479
doi:

Substances chimiques

TP63 protein, human 0
Tumor Suppressor Proteins 0
Trp63 protein, mouse 0
Trans-Activators 0
Enhancer of Zeste Homolog 2 Protein EC 2.1.1.43
Transcription Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadq0479

Auteurs

Yongchun Zhang (Y)

State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0009-0009-9949-0604

Dimitris Karagiannis (D)

Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0002-4394-1076

Helu Liu (H)

Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, Hainan, China.
ORCID: 0000-0002-4527-4115

Mi Lin (M)

Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.

Yinshan Fang (Y)

Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0001-9249-4498

Ming Jiang (M)

Center for Genetic Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310030, Zhejiang, China.

Xiao Chen (X)

Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0001-5059-8846

Supriya Suresh (S)

Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

Haidi Huang (H)

State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
ORCID: 0009-0005-1783-1016

Junjun She (J)

Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
ORCID: 0000-0001-5104-663X

Feiyu Shi (F)

Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
ORCID: 0000-0001-5691-1362

Jiangying Liu (J)

State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
ORCID: 0009-0008-5022-093X

Dan Luo (D)

State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
ORCID: 0009-0006-1407-5320

J Carlos Angel (JC)

Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0001-6531-7381

Guangtan Lin (G)

Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.

Patrick Yang (P)

Department of Internal Medicine, Westchester Medical Center/New York Medical College, Valhalla, NY 10595, USA.

Wael El-Rifai (W)

Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Miami Veterans Affairs Healthcare System, Miami, FL 33136, USA.
ORCID: 0000-0003-2101-6098

Alexander Zaika (A)

Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Miami Veterans Affairs Healthcare System, Miami, FL 33136, USA.

Anthony E Oro (AE)

Programin Epithelial Biology, Stanford University School of Medicine, Stanford 94305, CA, USA.
ORCID: 0000-0002-6261-138X

Kuancan Liu (K)

Central Laboratory, Xiang'an Hospital, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China.
ORCID: 0000-0002-2470-7479

Anil K Rustgi (AK)

Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.

Timothy C Wang (TC)

Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0002-2095-0121

Chao Lu (C)

Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0003-0982-8122

Jianwen Que (J)

Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0002-6540-6701

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Tumeurs gastro-intestinales › Tumeurs de l'oesophage › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Eucaryotes › Animaux › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif supérieur › Oesophage › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Carcinome neuroendocrine › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines du groupe Polycomb › Complexe répresseur Polycomb-2 › Protéine-2 homologue de l'activateur de Zeste › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Epigenetic regulation of p63 blocks...
questionsmedicales.fr › Cellules › Cellules endocrines › Cellules neuroendocrines › Epigenetic regulation of p63 blocks...