Refinement of the Drude Polarizable Force Field for Hexose Monosaccharides: Capturing Ring Conformational Dynamics with Enhanced Accuracy.


Journal

Journal of chemical theory and computation
ISSN: 1549-9626
Titre abrégé: J Chem Theory Comput
Pays: United States
ID NLM: 101232704

Informations de publication

Date de publication:
09 Oct 2024
Historique:
medline: 9 10 2024
pubmed: 9 10 2024
entrez: 9 10 2024
Statut: aheadofprint

Résumé

We present a revised version of the Drude polarizable carbohydrate force field (FF), focusing on refining the ring and exocyclic torsional parameters for hexopyranose monosaccharides. This refinement addresses the previously observed discrepancies between calculated and experimental NMR

Identifiants

pubmed: 39383338
doi: 10.1021/acs.jctc.4c00656
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Chythra J N (C)

Department of Chemistry, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat India - 382355.

Olgun Guvench (O)

Department of Pharmaceutical Sciences and Administration, School of Pharmacy, University of New England, 716 Stevens Avenue, Portland, Maine 04103, United States.

Alexander D MacKerell (AD)

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, United States.

Takumi Yamaguchi (T)

School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923-1292, Japan.

Sairam S Mallajosyula (SS)

Department of Chemistry, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat India - 382355.

Classifications MeSH