The synthetic chemistry of sarpagine-ajmaline-type alkaloids.
Ajmaline-type alkaloids
Azabicyclo[3.3.1]nonane
Sarpagine-related alkaloids
Synthetic strategy
Total synthesis
Journal
The Alkaloids. Chemistry and biology
ISSN: 1099-4831
Titre abrégé: Alkaloids Chem Biol
Pays: United States
ID NLM: 9812842
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
10
10
2024
pubmed:
10
10
2024
entrez:
9
10
2024
Statut:
ppublish
Résumé
The sarpagine-ajmaline type monoterpenoid indole alkaloids are among the most important groups of natural alkaloids, and the complex polycyclic and cage-like architectures present significant synthetic challenges. Because of their characteristic indole-fused azabicyclo[3.3.1]nonane structures and prominent biological activities, sarpagine-ajmaline related alkaloids have captured the attention of organic synthetic chemists for decades. In this chapter, the strategies employed in the synthesis of sarpagine-ajmaline related alkaloids are outlined, and the synthetic progress during the period of 2019-2023 is provided in detail. To provide potential targets for future synthetic endeavors, some sarpagine/ajmaline type alkaloids isolated in recent years with novel structures and biological activities are also summarized.
Identifiants
pubmed: 39384254
pii: S1099-4831(24)00016-6
doi: 10.1016/bs.alkal.2024.08.001
pii:
doi:
Substances chimiques
Ajmaline
1PON08459R
sarpagine
XD54MPV6VQ
Alkaloids
0
Indole Alkaloids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-119Informations de copyright
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