Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
received:
18
05
2023
accepted:
13
09
2024
medline:
10
10
2024
pubmed:
10
10
2024
entrez:
9
10
2024
Statut:
epublish
Résumé
Proliferative vitreoretinopathy is a vision-threatening response to penetrating ocular injury, for which there is no satisfactory treatment. In this disorder, retinal pigment epithelial cells, abandon their attachment to Bruch's membrane on the scleral side of the retina, transform into motile fibroblast-like cells, and migrate through the retinal wound to the vitreal surface of the retina, where they secrete membrane-forming proteins. Annexin A2 is a calcium-regulated protein that, in complex with S100A10, assembles plasmin-forming proteins at cell surfaces. Here, we show that, in proliferative vitreoretinopathy, recruitment of macrophages and directed migration of retinal pigment epithelial cells are annexin A2-dependent, and stimulated by macrophage inflammatory protein-1α/β. These factors induce translocation of annexin A2 to the cell surface, thus enabling retinal pigment epithelial cell migration following injury; our studies reveal further that treatment of mice with intraocular antibody to either annexin A2 or macrophage inflammatory protein dampens the development of proliferative vitreoretinopathy in mice.
Identifiants
pubmed: 39384746
doi: 10.1038/s41467-024-52675-x
pii: 10.1038/s41467-024-52675-x
doi:
Substances chimiques
Annexin A2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8757Subventions
Organisme : U.S. Department of Defense (United States Department of Defense)
ID : W81XWH141507
Organisme : U.S. Department of Defense (United States Department of Defense)
ID : W81XWH2110390
Informations de copyright
© 2024. The Author(s).
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