Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.


Journal

The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115

Informations de publication

Date de publication:
10 Oct 2024
Historique:
received: 27 05 2024
accepted: 10 09 2024
revised: 28 08 2024
medline: 10 10 2024
pubmed: 10 10 2024
entrez: 9 10 2024
Statut: aheadofprint

Résumé

A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2-5) were isolated from a culture broth of Aspergillus insuetus BF-1613. The chemical structure of 1 was elucidated by extensive spectroscopic analyses, including MS and NMR. Compound 1 has a drimane-type sesquiterpene core with a 2'E,4'E,6'E-octatrienoate side chain. All these drimane sesquiterpene esters inhibited both sterol O-acyl transferase 1 (SOAT1) and 2 (SOAT2), but exhibited slightly potent inhibition against SOAT1 than SOAT2 with selectivity index (SI) [log (IC

Identifiants

pubmed: 39385005
doi: 10.1038/s41429-024-00774-8
pii: 10.1038/s41429-024-00774-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 18KK0219

Informations de copyright

© 2024. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.

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Auteurs

Elyza Aiman Azizah Nur (EAA)

Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Tokyo, Japan.
Department of Microbial Chemistry, School of Pharmacy, Kitasato University, Tokyo, Japan.

Keisuke Kobayashi (K)

Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Tokyo, Japan.
Department of Microbial Chemistry, School of Pharmacy, Kitasato University, Tokyo, Japan.

Rio Tejima (R)

Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

Yosuke Katada (Y)

Department of Microbial Chemistry, School of Pharmacy, Kitasato University, Tokyo, Japan.

Hiroshi Tomoda (H)

Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Tokyo, Japan.
Department of Microbial Chemistry, School of Pharmacy, Kitasato University, Tokyo, Japan.

Taichi Ohshiro (T)

Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan. ohshirot@pharm.kitasato-u.ac.jp.
Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Tokyo, Japan. ohshirot@pharm.kitasato-u.ac.jp.
Department of Microbial Chemistry, School of Pharmacy, Kitasato University, Tokyo, Japan. ohshirot@pharm.kitasato-u.ac.jp.

Classifications MeSH