Immune modulatory effects of tulathromycin, gamithromycin, and oxytetracycline in cattle.
Cytokines
Lymphocytes
Macrophages
Metaphylaxis
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
received:
06
02
2024
accepted:
28
08
2024
medline:
10
10
2024
pubmed:
10
10
2024
entrez:
9
10
2024
Statut:
epublish
Résumé
Certain classes of antibiotics, including tetracyclines and macrolides, are known to exert immune suppressive effects in other species but the immune modulatory effects of these antibiotics have not been previously studied in cattle. To address this question, we investigated the effects of oxytetracycline, gamithromycin, and tulathromycin on T cell and macrophage responses to activation, using in vitro assays. In addition, we assessed the impact of these antibiotics on T cell responses in vivo following treatment of healthy cattle with currently recommended doses of each of the three antibiotics. We found that all 3 antibiotics markedly suppressed T cell proliferation in vitro at relevant therapeutic drug concentrations and significantly suppressed macrophage activation responses to LPS. In cattle treated with a single dose of each antibiotic, we observed significant suppression of T cell proliferation and cytokine production beginning as early as 6 h after administration, with increasing immune suppression observed at 48 h. Taken together, these results indicate that commonly used antibiotics in cattle exert significant immune modulatory activity, in addition to their antimicrobial activity. These off-target effects should be considered when using antibiotics for prophylaxis or metaphylaxis in high-risk dairy or beef cattle (192 words).
Identifiants
pubmed: 39385141
doi: 10.1186/s12917-024-04254-x
pii: 10.1186/s12917-024-04254-x
doi:
Substances chimiques
tulathromycin
Q839I13422
Oxytetracycline
X20I9EN955
Heterocyclic Compounds
0
Anti-Bacterial Agents
0
gamithromycin
ZE856183S0
Disaccharides
0
Macrolides
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
456Informations de copyright
© 2024. The Author(s).
Références
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