Implementing differentially pigmented skin models for predicting drug response variability across human ancestries.
AI
Cell model
Diversity
Drug Bioavailability
Equity
IVIVE
Inclusivity
Melanin
NAM
Pharmacodynamics
Pharmacokinetics
Phototoxicity
Journal
Human genomics
ISSN: 1479-7364
Titre abrégé: Hum Genomics
Pays: England
ID NLM: 101202210
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
received:
01
07
2024
accepted:
21
09
2024
medline:
10
10
2024
pubmed:
10
10
2024
entrez:
10
10
2024
Statut:
epublish
Résumé
Persistent racial disparities in health outcomes have catalyzed legislative reforms and heightened scientific focus recently. However, despite the well-documented properties of skin pigments in binding drug compounds, their impact on therapeutic efficacy and adverse drug responses remains insufficiently explored. This perspective examines the intricate relationships between variation in melanin-based skin pigmentation and pharmacokinetics and -dynamics, highlighting the need for considering diversity in skin pigmentation as a variable to advance the equitability of pharmacological interventions. The article provides guidelines on the selection of New Approach Methods (NAMs) to foster inclusive study designs in preclinical drug development pipelines, leading to an improved level of translatability to the clinic.
Identifiants
pubmed: 39385300
doi: 10.1186/s40246-024-00677-7
pii: 10.1186/s40246-024-00677-7
doi:
Substances chimiques
Melanins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113Subventions
Organisme : NIH HHS
ID : R35GM151194
Pays : United States
Informations de copyright
© 2024. The Author(s).
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