Perinephric Extramedullary Disease in Multiple Myeloma.
Journal
Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109
Informations de publication
Date de publication:
10 Oct 2024
10 Oct 2024
Historique:
medline:
10
10
2024
pubmed:
10
10
2024
entrez:
10
10
2024
Statut:
aheadofprint
Résumé
Extramedullary disease represents an aggressive form of multiple myeloma occurring outside the skeleton and is a poor prognostic indicator. Extramedullary disease most commonly involves the skin, muscle, pleura, lymph nodes, liver, and central nervous system. Infrequently, extramedullary disease can involve the kidneys or perirenal space. We present 3 cases of perirenal involvement of extramedullary disease on 18F-FDG PET/CT confirmed with tissue sampling as plasma cell infiltration. Within the limitation of physiologic activity in the kidneys due to 18F-FDG excretion, close consideration is essential when evaluating multiple myeloma patients for genitourinary involvement as it can resemble other malignancies, hemorrhage, or renal injury.
Identifiants
pubmed: 39385388
doi: 10.1097/RLU.0000000000005520
pii: 00003072-990000000-01334
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest and sources of funding: none declared.
Références
Rajkumar SV. Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. Am J Hematol. 2022;97:1086–1107.
Hall MN, Jagannathan JP, Ramaiya NH, et al. Imaging of extraosseous myeloma: CT, PET/CT, and MRI features. Am J Roentgenol. 2010;195:1057–1065.
Bladé J, Beksac M, Caers J, et al. Extramedullary disease in multiple myeloma: a systematic literature review. Blood Cancer J. 2022;12:45.
Gülbahar Ateş S, Uçmak G. A rare extramedullary involvement site in patients with multiple myeloma: stomach. Clin Nucl Med. 2022;47:e702–e703.
Strauss D, Sachpekidis C, Dapunt U, et al. Unusual extramedullary manifestation in multiple myeloma: bilateral synchronous testicular infiltration. Clin Nucl Med. 2023;48:e76–e77.
Civan C, Apaydin Arikan E, Has Simsek D, et al. Bilateral testicular mass presenting as a rare manifestation of extramedullary plasmacytoma on 18F-FDG PET/CT. Clin Nucl Med. 2022;47:e296–e297.
Oshima K, Kanda Y, Nannya Y, et al. Clinical and pathologic findings in 52 consecutively autopsied cases with multiple myeloma. Am J Hematol. 2001;67:1–5.
Moulopoulos LA, Granfield CA, Dimopoulos MA, et al. Extraosseous multiple myeloma: imaging features. AJR Am J Roentgenol. 1993;161:1083–1087.
Tirumani SH, Shinagare AB, Jagannathan JP, et al. MRI features of extramedullary myeloma. Am J Roentgenol. 2014;202:803–810.
Lu YY, Chen JH, Lin WY, et al. FDG PET or PET/CT for detecting intramedullary and extramedullary lesions in multiple myeloma: a systematic review and meta-analysis. Clin Nucl Med. 2012;37:833–837.
Sered S, Nikolaidis P. CT findings of perirenal plasmacytoma. AJR Am J Roentgenol. 2003;181:888.