Fatigue in early multiple sclerosis: MRI metrics of neuroinflammation, relapse and neurodegeneration.

fatigue magnetic resonance imaging multiple sclerosis neurodegeneration neuroinflammation

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2024
Historique:
received: 22 02 2024
revised: 27 05 2024
accepted: 13 08 2024
medline: 10 10 2024
pubmed: 10 10 2024
entrez: 10 10 2024
Statut: epublish

Résumé

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the brain and spinal cord. Fatigue is a common disabling symptom from MS onset, however the mechanisms by which underlying disease processes cause fatigue remain unclear. Improved pathophysiological understanding offers potential for improved treatments for MS-related fatigue. MRI provides insights into

Identifiants

DOI: 10.1093/braincomms/fcae278 PMID: 39386090 PMC: PMC11462441
pubmed: 39386090
doi: 10.1093/braincomms/fcae278
pii: fcae278
pmc: PMC11462441
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcae278

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest relevant to this paper. D.S.R. received research support from companies Abata Therapeutics, Sanofi-Genzyme and Vertex Pharmaceuticals, unrelated to this paper.

Auteurs

Rozanna Meijboom (R)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Edinburgh Imaging, University of Edinburgh, Edinburgh EH16 4SB, UK.
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
ORCID: 0000-0003-3346-260X

Peter Foley (P)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
ORCID: 0000-0001-7039-2976

Niall J J MacDougall (NJJ)

Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow G51 4TF, UK.

Yair Mina (Y)

Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
ORCID: 0000-0003-2311-6623

Elizabeth N York (EN)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Edinburgh Imaging, University of Edinburgh, Edinburgh EH16 4SB, UK.
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
ORCID: 0000-0002-4310-8607

Agniete Kampaite (A)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Edinburgh Imaging, University of Edinburgh, Edinburgh EH16 4SB, UK.

Daisy Mollison (D)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.

Patrick K A Kearns (PKA)

Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.

Nicole White (N)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Edinburgh Imaging, University of Edinburgh, Edinburgh EH16 4SB, UK.

Michael J Thrippleton (MJ)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Edinburgh Imaging, University of Edinburgh, Edinburgh EH16 4SB, UK.

Katy Murray (K)

Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
Department of Neurology, Forth Valley Royal Hospital, Larbert FK5 4WR, UK.

Maria Del C Valdés Hernández (MDC)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Edinburgh Imaging, University of Edinburgh, Edinburgh EH16 4SB, UK.

Daniel S Reich (DS)

Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
ORCID: 0000-0002-2628-4334

Peter Connick (P)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.

Steven Jacobson (S)

Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.

Govind Nair (G)

Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
Quantitative MRI Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.

Siddharthan Chandran (S)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.

Adam D Waldman (AD)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Edinburgh Imaging, University of Edinburgh, Edinburgh EH16 4SB, UK.
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.

Classifications MeSH