TNFSF13 insufficiency disrupts human colonic epithelial cell-mediated B cell differentiation.

Cytokines mediating epithelial and immune cell interactions modulate mucosal healing-a process that goes awry with chronic inflammation as in inflammatory bowel disease. TNFSF13 is a cytokine important for B cell maturation and function, but roles for epithelial TNFSF13 and putative contribution to inflammatory bowel disease are poorly understood. We evaluated functional consequences of a novel monoallelic Epithelial TNFSF13 regulates colonic epithelial growth and epithelial-B cell interactions.