Multimodal physiological correlates of dyspnea ratings during breath-holding in healthy humans.
Air hunger
Apnea
Breath-holding
Breathing drive
Dyspnea
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
10 Oct 2024
10 Oct 2024
Historique:
received:
25
03
2024
accepted:
25
09
2024
medline:
11
10
2024
pubmed:
11
10
2024
entrez:
10
10
2024
Statut:
aheadofprint
Résumé
Dyspnea is associated with fear and intense suffering and is often assessed using visual analog scales (VAS) or numerical rating scales (NRS). However, the physiological correlates of such ratings are not well known. Using the voluntary breath-holding model of induced dyspnea, we studied healthy volunteers to investigate the temporal relationship between dyspnea, the neural drive to breathe assessed in terms of involuntary thoracoabdominal movements (ITMs) and neurovegetative responses. Twenty-three participants (10 men; median [interquartile range] age 21 [20-21]) performed three consecutive breath-holds with the continuous assessment of dyspnea (urge-to-breathe) using a 10 cm VAS, thoracic and abdominal circumferences measured with piezoelectric belt-mounted transducers, heart rate and heart rate variability (HRV), and galvanic skin response (GSR). Urge-to-breathe VAS at the onset of ITMs (gasping point) was identified visually or algorithmically. Urge-to-breathe VAS at the end of the breath-hold was 9.7 [8.6-10] cm. Total breath-hold duration was 93 [69-130] s. Urge-to-breathe VAS, ITM, heart rate, HRV, and GSR significantly increased during breath-hold. Urge-to-breathe VAS correlated with the magnitude of the thoracic and abdominal movements (rho = 0.51 and rho = 0.59, respectively, p < 0.001). The urge-to-breathe ratings corresponding with ITM onset were 3.0 [2.0-4.7] cm and 3.0 [1.0-4.0] cm for visual and algorithmic detection, respectively (p = 0.782). An urge-to-breathe VAS of 3 cm (30% of full scale on a 10 cm VAS) corresponds to a physiological turning point during the physiological response to voluntary breath-holding in healthy humans.
Identifiants
pubmed: 39387934
doi: 10.1007/s00421-024-05627-8
pii: 10.1007/s00421-024-05627-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : La Fondation pour la Recherche Médicale
ID : FDM201906008876
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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