P2 purinergic receptor expression and function in tumor-related immune cells.

Immune cells Macrophages Neutrophils P2 purinergic receptor T-cells Tumor microenvironment

Journal

Purinergic signalling
ISSN: 1573-9546
Titre abrégé: Purinergic Signal
Pays: Netherlands
ID NLM: 101250499

Informations de publication

Date de publication:
10 Oct 2024
Historique:
received: 17 04 2024
accepted: 27 09 2024
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 10 10 2024
Statut: aheadofprint

Résumé

P2 purinergic receptor expression is dysregulated in multiple cancer subtypes and is associated with worse outcomes. Studies identify roles for P2 purinergic receptors in tumor cells that drive disease aggressiveness. There is also sufficient evidence that P2 purinergic receptor expression within the tumor microenvironment (TME) is critical for disease initiation and progression. Immune cells constitute a significant component of the TME and display both tumorigenic and anti-tumorigenic potential. Studies pre-dating the investigation of P2 purinergic receptors in cancer identify P2 receptor expression on multiple immune cells including macrophages, neutrophils, T-cells, and dendritic cells; all of which are implicated in tumor initiation, tumor promotion, or response to treatment. Herein, we discuss P2 purinergic receptor expression and function in tumor-related immune cells. We provide a rationale for further investigations of P2 purinergic receptors within the TME to better define the mechanistic pathways of inflammation-mediate tumorigenesis and explore P2 purinergic receptors as potential targets for novel immunotherapeutic approaches.

Identifiants

pubmed: 39387963
doi: 10.1007/s11302-024-10054-7
pii: 10.1007/s11302-024-10054-7
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature B.V.

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Auteurs

Vahinipriya Manoharan (V)

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Oluwafemi O Adegbayi (OO)

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Janielle P Maynard (JP)

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. maynard@jhmi.edu.
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. maynard@jhmi.edu.

Classifications MeSH