Liver Vein Deprivation Versus Portal Vein Embolization: Retrospective Review of Safety and Effectiveness.

To compare the safety and effectiveness of liver vein deprivation (LVD) and portal vein embolization (PVE) in patients scheduled to undergo liver resection. This retrospective cohort study included 59 patients who underwent either PVE (n = 28) or LVD (n = 31) in preparation for liver resection. The primary outcome was percent change in future liver remnant volume (FLRV). Secondary endpoints were degree of hypertrophy (DH) and kinetic growth rate (KGR). Low baseline FLRV, time interval in days between the procedure and follow-up imaging (Ti) positively impacted the primary and secondary endpoints in both groups. Percent change in FLRV was higher in the LVD group (52.8% ± 5.3%) than in the PVE group (22.3% ± 3.0%; P <.001). DH was also higher in the LVD group (15.4% ± 1.7%) than in the PVE group (6.4% ± 0.9%; P <.001). KGR did not differ significantly between groups (LVD, 0.54%/d ± 0.06%/d; PVE, 0.35%/d ± 0.1%/d; P =0.239). When patients with baseline standardized FLRV > 35% were excluded from the analysis, LVD group demonstrated higher values than the PVE group in KGR (0.57%/d ± 0.06%/d vs 0.29%/d ± 0.05%/d; P <.001), percent change in FLRV (64.2% ± 6.0% vs 25.9% ± 4.3%; P <.001), and DH (15.4% ± 1.4% vs 6.6% ± 1.0%; P <.001). No adverse events were noted in either group. LVD appears to be safe and may be superior to PVE in inducing hypertrophy of FLR in patients scheduled to undergo surgical resection.

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