Trends in the incidence and prevalence of cirrhosis in Manitoba, Canada: A population-based study (2010-2019).

Gender disparity epidemiology health policy, chronic liver disease

Journal

Annals of hepatology
ISSN: 1665-2681
Titre abrégé: Ann Hepatol
Pays: Mexico
ID NLM: 101155885

Informations de publication

Date de publication:
08 Oct 2024
Historique:
received: 17 01 2024
revised: 28 06 2024
accepted: 22 08 2024
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 10 10 2024
Statut: aheadofprint

Résumé

The burden of chronic liver disease and cirrhosis continues to increase in North America. We sought to estimate the incidence and prevalence of cirrhosis in Manitoba, Canada over time and assess changes in trends between 2010-2019. We performed a population-based study using Manitoba administrative health care data, and two validated case-finding algorithms. Annual incidence and prevalence rates were estimated using a generalized linear model with generalized estimating equations, adjusting for age and sex. Changes in estimates were tested using linear trend regression models. Two algorithms estimated the number of prevalent cirrhosis to be 16,140 and 29,943 respectively. The age- and sex-adjusted incidence rates increased over the study (from 149 to 264 cases per 100,000 population in 2010, to 177 to 388 cases per 100,000 population in 2019). Cirrhosis incidence increased annually by 2-6%, with the largest increase (6-8% 95% CI 7-9%, p <0.0001) in those aged 18-44 years. Irrespective of the algorithm used, females consistently exhibited higher cirrhosis incidence and prevalence compared to males over time (P <0.0001). Prevalence demonstrated an upward trend among all age groups over time for both algorithms (P < 0.0001). This population-based study highlights concerning temporal trends in cirrhosis, characterized by rising annual incidence and prevalence estimates, particularly among young adults and females. These findings underscore the urgent need for comprehensive strategies that encompass prevention, early detection, and the delivery of high-quality healthcare and public health initiatives to effectively tackle this escalating health burden.

Identifiants

DOI: 10.1016/j.aohep.2024.101581 PMID: 39389266
pubmed: 39389266
pii: S1665-2681(24)00364-8
doi: 10.1016/j.aohep.2024.101581
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101581

Informations de copyright

Copyright © 2024. Published by Elsevier España, S.L.U.

Déclaration de conflit d'intérêts

Conflicts of interest Financial Disclosures: Dr. Singh has been on advisory boards or consulted for Abbvie Canada, Amgen Canada, Roche Canada, Sandoz Canada, Organon Canada, Eli Lilly Canada, Takeda Canada, Pendopharm Inc, and Guardant Health, Inc. and has received research funding for an investigator-initiated study from Pfizer. Declarations of interest from all other authors: none

Auteurs

Nabiha Faisal (N)

Department of Internal Medicine, University of Manitoba, GC430-820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada; Department of Community Health Sciences, University of Manitoba, Room S113 - 750 Bannatyne Avenue, University of Manitoba (Bannatyne campus), Winnipeg, MB, R3E 0W3 Canada. Electronic address: Nabiha.Faisal@umanitoba.ca.

Lisa M Lix (LM)

Department of Community Health Sciences, University of Manitoba, Room S113 - 750 Bannatyne Avenue, University of Manitoba (Bannatyne campus), Winnipeg, MB, R3E 0W3 Canada; Manitoba Centre of Health Policy, University of Manitoba, Room 408-727 McDermot Ave., Winnipeg, MB, R3E 3P5, Canada.

Randy Walld (R)

Manitoba Centre of Health Policy, University of Manitoba, Room 408-727 McDermot Ave., Winnipeg, MB, R3E 3P5, Canada.

Alexander Singer (A)

Department of Family Medicine, University of Manitoba Canada, S100, 750 Bannatyne Avenue, University of Manitoba (Bannatyne campus), Winnipeg, MB, R33 0W2 Canada.

Leanne Kosowan (L)

Department of Family Medicine, University of Manitoba Canada, S100, 750 Bannatyne Avenue, University of Manitoba (Bannatyne campus), Winnipeg, MB, R33 0W2 Canada.

Harminder Singh (H)

Department of Internal Medicine, University of Manitoba, GC430-820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada; Department of Community Health Sciences, University of Manitoba, Room S113 - 750 Bannatyne Avenue, University of Manitoba (Bannatyne campus), Winnipeg, MB, R3E 0W3 Canada.

Eberhard Renner (E)

Department of Internal Medicine, University of Manitoba, GC430-820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.

Alyson Mahar (A)

Department of Community Health Sciences, University of Manitoba, Room S113 - 750 Bannatyne Avenue, University of Manitoba (Bannatyne campus), Winnipeg, MB, R3E 0W3 Canada; School of Nursing, Queen's University, 92 Barrie Street Kingston, Ontario, K7L 3N6, Canada.

Classifications MeSH