A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: the MiSBIE study.

allostasis metabolism mitochondrial disorders mtDNA psychobiology stress

Journal

Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516

Informations de publication

Date de publication:
09 Oct 2024
Historique:
received: 21 07 2024
revised: 16 08 2024
accepted: 16 08 2024
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 10 10 2024
Statut: aheadofprint

Résumé

Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain-body, and mind-mitochondria processes relevant to medicine and public health.

Identifiants

DOI: 10.1016/j.tem.2024.08.006 PMID: 39389809
pubmed: 39389809
pii: S1043-2760(24)00225-X
doi: 10.1016/j.tem.2024.08.006
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors have no competing interests to declare.

Auteurs

Catherine Kelly (C)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Caroline Trumpff (C)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Carlos Acosta (C)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Stephanie Assuras (S)

Department of Clinical Neuropsychology, Division of Cognitive Neuroscience, Columbia University Irving Medical Center, New York, NY, USA.

Jack Baker (J)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Sophia Basarrate (S)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Alexander Behnke (A)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA; Clinical and Biological Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.

Ke Bo (K)

Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.

Natalia Bobba-Alves (N)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Frances A Champagne (FA)

Department of Psychology, University of Texas at Austin, Austin, TX, USA.

Quinn Conklin (Q)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.

Marissa Cross (M)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Philip De Jager (P)

Center for Translational and Computational Neuroimmunology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.

Kris Engelstad (K)

H. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.

Elissa Epel (E)

Weill Institute for Neurosciences, Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.

Soah G Franklin (SG)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Michio Hirano (M)

H. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.

Qiuhan Huang (Q)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Alex Junker (A)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Robert-Paul Juster (RP)

Department of Psychiatry and Addiction, University of Montreal, Montreal, Quebec, Canada.

Darshana Kapri (D)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Clemens Kirschbaum (C)

Faculty of Psychology, Institute of Biopsychology, Technical University Dresden, Dresden, Germany.

Mangesh Kurade (M)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Vincenzo Lauriola (V)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Shufang Li (S)

H. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.

Cynthia C Liu (CC)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Grace Liu (G)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Bruce McEwen (B)

Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA.

Marlon A McGill (MA)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Kathleen McIntyre (K)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Anna S Monzel (AS)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Jeremy Michelson (J)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Aric A Prather (AA)

Weill Institute for Neurosciences, Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.

Eli Puterman (E)

School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.

Xiomara Q Rosales (XQ)

H. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.

Peter A Shapiro (PA)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA; Consultation-Liaison Psychiatry, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

David Shire (D)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

George M Slavich (GM)

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.

Richard P Sloan (RP)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Janell L M Smith (JLM)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Marisa Spann (M)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Julie Spicer (J)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Gabriel Sturm (G)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Sophia Tepler (S)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Michel Thiebaut de Schotten (MT)

Brain Connectivity and Behavior Laboratory, Paris, France; Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, France.

Tor D Wager (TD)

Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.

Martin Picard (M)

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA; H. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. Electronic address: martin.picard@columbia.edu.

Classifications MeSH