Clausena harmandiana root extract ameliorates Aβ
Clausena Harmandiana
Amyloid-β
Apoptosis
Oxidative stress
Spatial memory
Journal
BMC complementary medicine and therapies
ISSN: 2662-7671
Titre abrégé: BMC Complement Med Ther
Pays: England
ID NLM: 101761232
Informations de publication
Date de publication:
10 Oct 2024
10 Oct 2024
Historique:
received:
30
10
2023
accepted:
23
09
2024
medline:
11
10
2024
pubmed:
11
10
2024
entrez:
10
10
2024
Statut:
epublish
Résumé
Clausena harmandiana (CH), commonly known as song fa dong, was a medicinal plant traditionally used to treat illnesses and as a health tonic. CH root extract (CHRE) exhibited various bioactivities, including neuroprotective, antioxidant, antimicrobial, antifungal, anti-inflammatory, and anti-cancer effects. However, CHRE data on neuroprotective in AD-like animal models were still scarce. This study aimed to investigate the effects of CHRE on Aβ Forty-eight adult male Sprague-Dawley rats (250-300 g) were classified as sham control (SC), V+Aβ, Vit C+Aβ, CHRE125+Aβ, CHRE250+Aβ, and CHRE500+Aβ (n = 8 in each group). Animals were orally administered with 0.5% sodium carboxymethylcellulose, vitamin C (200 mg/kg BW), or CHRE (125, 250, and 500 mg/kg BW) and were untreated for 35 days. On day 21, all treated rats were injected with 1 µl of aggregated Aβ Pretreatment with CHRE at all doses could alleviate spatial learning and memory defects. CHRE also improved morphological changes and a decrease in neuronal density in CA1 and CA3 regions. Additionally, CHRE significantly increased the activities of antioxidant enzymes (SOD, CAT, GPx) and Nrf2 expression. This was coupled with significantly decreased MDA levels and active caspase-3 expression in the hippocampus of Aβ Our findings suggested that CHRE ameliorated cognitive deficits and exhibited neuroprotective effects by reducing free radical damage and mitigating neuronal abnormality and neuronal death.
Sections du résumé
BACKGROUND
BACKGROUND
Clausena harmandiana (CH), commonly known as song fa dong, was a medicinal plant traditionally used to treat illnesses and as a health tonic. CH root extract (CHRE) exhibited various bioactivities, including neuroprotective, antioxidant, antimicrobial, antifungal, anti-inflammatory, and anti-cancer effects. However, CHRE data on neuroprotective in AD-like animal models were still scarce.
OBJECTIVES
OBJECTIVE
This study aimed to investigate the effects of CHRE on Aβ
METHODS
METHODS
Forty-eight adult male Sprague-Dawley rats (250-300 g) were classified as sham control (SC), V+Aβ, Vit C+Aβ, CHRE125+Aβ, CHRE250+Aβ, and CHRE500+Aβ (n = 8 in each group). Animals were orally administered with 0.5% sodium carboxymethylcellulose, vitamin C (200 mg/kg BW), or CHRE (125, 250, and 500 mg/kg BW) and were untreated for 35 days. On day 21, all treated rats were injected with 1 µl of aggregated Aβ
RESULTS
RESULTS
Pretreatment with CHRE at all doses could alleviate spatial learning and memory defects. CHRE also improved morphological changes and a decrease in neuronal density in CA1 and CA3 regions. Additionally, CHRE significantly increased the activities of antioxidant enzymes (SOD, CAT, GPx) and Nrf2 expression. This was coupled with significantly decreased MDA levels and active caspase-3 expression in the hippocampus of Aβ
CONCLUSIONS
CONCLUSIONS
Our findings suggested that CHRE ameliorated cognitive deficits and exhibited neuroprotective effects by reducing free radical damage and mitigating neuronal abnormality and neuronal death.
Identifiants
pubmed: 39390478
doi: 10.1186/s12906-024-04662-4
pii: 10.1186/s12906-024-04662-4
doi:
Substances chimiques
Plant Extracts
0
Amyloid beta-Peptides
0
Neuroprotective Agents
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
364Subventions
Organisme : Thailand Research Fund
ID : DBG6080006
Organisme : Invitation Research Fund
ID : IN63263
Organisme : Individual research grant of Walailak University
ID : WU66248
Informations de copyright
© 2024. The Author(s).
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