Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury.


Journal

Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974

Informations de publication

Date de publication:
10 Oct 2024
Historique:
received: 24 06 2024
accepted: 28 09 2024
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 10 10 2024
Statut: epublish

Résumé

Progranulin (PGRN), which is produced in neurons and microglia, is a neurotrophic and anti-inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal dementia, and PGRN knockout (KO) mice are a model for dementia. In addition, PGRN KO mice exhibit severe phenotypes in models of traumatic or ischemic central nervous system (CNS) disorders, including traumatic brain injury (TBI). It is unknown whether restoration of progranulin expression in neurons (and not in microglia) might be sufficient to prevent excessive TBI-evoked brain damage. To address this question, we generated mice with Nestin-Cre-driven murine PGRN expression in a PGRN KO line (PGRN-KO

Identifiants

pubmed: 39390556
doi: 10.1186/s12974-024-03249-7
pii: 10.1186/s12974-024-03249-7
doi:

Substances chimiques

Progranulins 0
Grn protein, mouse 0
Neuroprotective Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

257

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Sudena Wang (S)

Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1 (Bld. 505), 55131, Mainz, Germany.

Marc-Philipp Weyer (MP)

Institute for Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, Theodor Stern Kai 7 | Bd 74-75, Rm 4.101a, 60590, Frankfurt am Main, Germany.

Regina Hummel (R)

Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1 (Bld. 505), 55131, Mainz, Germany.

Annett Wilken-Schmitz (A)

Institute for Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, Theodor Stern Kai 7 | Bd 74-75, Rm 4.101a, 60590, Frankfurt am Main, Germany.

Irmgard Tegeder (I)

Institute for Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, Theodor Stern Kai 7 | Bd 74-75, Rm 4.101a, 60590, Frankfurt am Main, Germany.

Michael K E Schäfer (MKE)

Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1 (Bld. 505), 55131, Mainz, Germany. Michael.Schaefer@unimedizin-mainz.de.
Focus Program Translational Neurosciences (FTN) of the Johannes Gutenberg-University Mainz, Mainz, Germany. Michael.Schaefer@unimedizin-mainz.de.
Research Center for Immunotherapy (FZI) of the Johannes Gutenberg-University Mainz, Mainz, Germany. Michael.Schaefer@unimedizin-mainz.de.

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