Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying Its Stability

Journal

Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536

Informations de publication

Date de publication:
11 Oct 2024
Historique:
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 11 10 2024
Statut: aheadofprint

Résumé

What happens to macromolecules

Identifiants

DOI: 10.1021/acs.analchem.4c02309 PMID: 39392424
pubmed: 39392424
doi: 10.1021/acs.analchem.4c02309
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Yue Huang (Y)

Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, California 94080, United States.
ORCID: 0000-0003-2788-0856

Hui Yin Tan (HY)

Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, California 94080, United States.
ORCID: 0000-0001-9400-566X

Jiaqi Yuan (J)

Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, California 94080, United States.

Ruipeng Mu (R)

Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, California 94080, United States.

Junyan Yang (J)

Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, California 94080, United States.

Kathryn Ball (K)

Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB21 6GH, United Kingdom.

Balakumar Vijayakrishnan (B)

TTD, Oncology R&D, AstraZeneca, London E1 2AX, United Kingdom.
ORCID: 0000-0002-0329-8565

Luke Masterson (L)

TTD, Oncology R&D, AstraZeneca, London E1 2AX, United Kingdom.

Krista Kinneer (K)

Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, Maryland 20878, United States.

Nadia Luheshi (N)

Oncology R&D, AstraZeneca, Cambridge CB2 8PA, United Kingdom.

Meina Liang (M)

Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, California 94080, United States.

Anton I Rosenbaum (AI)

Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, California 94080, United States.
ORCID: 0000-0003-1939-951X

Classifications MeSH