Parkinson biomarker determination with an Au microflower-enhanced electrochemical immunosensor using non-Faradaic capacitance measurements.
Au flowers
Electrochemical immunosensor
Modified electrode
Non-Faradaic electrochemical impedance spectroscopy
PARK7/DJ-1
Parkinson’s disease
Journal
Mikrochimica acta
ISSN: 1436-5073
Titre abrégé: Mikrochim Acta
Pays: Austria
ID NLM: 7808782
Informations de publication
Date de publication:
11 10 2024
11 10 2024
Historique:
received:
12
08
2024
accepted:
03
10
2024
medline:
11
10
2024
pubmed:
11
10
2024
entrez:
11
10
2024
Statut:
epublish
Résumé
This work comprehends the development and characterization of a carbon black-based electrode modified with Au microflowers to increase its effect as a capacitance biosensor for the determination of PARK7/DJ-1. Due to its high surface-to-volume ratio and biocompatibility, Au particles are suitable for antibody binding, and by monitoring surface capacitance, it is possible to identify the immune-pair interaction. Au microflowers allowed the adequate immobilization of Parkinsonian-related proteins: PARK7/DJ-1 and its antibody. The protein is associated with several antioxidant mechanisms, but its abnormal concentrations or mutations can be the cause of the loss of dopaminergic neurons, leading to Parkinson's disease. The device was characterized by scanning electron microscopy and cyclic voltammetry, revealing the flower-like structures and the electrochemically-interest enhancements they provide, such as increased heterogeneous electron transfer rate coefficient and electroactive area. The self-assembled monolayers of different molecules were optimized with the aid of 2
Identifiants
pubmed: 39392501
doi: 10.1007/s00604-024-06747-w
pii: 10.1007/s00604-024-06747-w
doi:
Substances chimiques
Gold
7440-57-5
Protein Deglycase DJ-1
EC 3.1.2.-
Biomarkers
0
Antibodies, Immobilized
0
PARK7 protein, human
EC 3.1.2.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
663Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2019/23342-0
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2023/10141-2
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2019/23342-0
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.504861/2020-00
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.504861/2020-00
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 380632/2023-3
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 380632/2023-3
Organisme : Financiadora de Estudos e Projetos
ID : MARTMA, 01.22.0179.00
Organisme : Financiadora de Estudos e Projetos
ID : MARTMA, 01.22.0179.00
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
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