"Try until the last?"-the relevance of fresh embryo transfer outcomes for subsequent same-cohort vitrified-warmed cycles.
Cryopreservation
Embryo cohort
Live birth rate
Prediction model
Pregnancy rate
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
11 Oct 2024
11 Oct 2024
Historique:
received:
27
08
2024
accepted:
01
10
2024
medline:
11
10
2024
pubmed:
11
10
2024
entrez:
11
10
2024
Statut:
aheadofprint
Résumé
Taking into consideration earlier attempts at assisted reproduction and previous pregnancies allows a more differentiated approach when counseling couples regarding their chances in assisted reproductive treatments. The aim of this study was to investigate whether the outcome of fresh embryo transfers affects subsequent same-cohort vitrified-warmed cycles. This retrospective cohort study analyzes the outcome of all fresh and frozen embryo transfers (n = 8118) between January 1, 2011, and December 31, 2022. All women who received fresh or frozen embryo transfers at Kepler University Hospital Linz were included. The use of donor eggs, previously cryopreserved oocytes, and freeze-all cycles were excluded from the analysis. Positive serum βhCG after a fresh cycle has a significant impact on the chances of positive βhCG in a subsequent vitrified-warmed cycle (36.3% [33.2%, 39.5%]; P = 0.002). Negative βhCG after a fresh cycle does not predict the outcome of the following same-cohort embryo transfer (33.1% [30.7%, 35.7%], P = 0.726). Pregnancy rates of the first, second, third, and fourth same-cohort vitrified-warmed embryo transfer remain continuously high, with 32.8%, 30.8%, 28.9%, and 27.1%, respectively. Positive serum βhCG after a fresh embryo transfer has a positive predictive value for the outcome of a subsequent vitrified-warmed embryo transfer. Couples with a negative fresh cycle should not be discouraged from continuing fertility treatment using same-cohort frozen embryos. This study was prospectively registered at the German Clinical Trials Register on September 5, 2023 (DRKS00032552).
Identifiants
pubmed: 39392518
doi: 10.1007/s10815-024-03285-5
pii: 10.1007/s10815-024-03285-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
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