Microbes as medicine.

live microbial therapy microbial ecology postbiotics prebiotics probiotics synbiotics

Journal

Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858

Informations de publication

Date de publication:
11 Oct 2024
Historique:
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 11 10 2024
Statut: aheadofprint

Résumé

Over the last two decades, advancements in sequencing technologies have significantly deepened our understanding of the human microbiome's complexity, leading to increased concerns about the detrimental effects of antibiotics on these intricate microbial ecosystems. Concurrently, the rise in antimicrobial resistance has intensified the focus on how beneficial microbes can be harnessed to treat diseases and improve health and offer potentially promising alternatives to traditional antibiotic treatments. Here, we provide a comprehensive overview of both established and emerging microbe-centric therapies, from probiotics to advanced microbial ecosystem therapeutics, examine the sophisticated ways in which microbes are used medicinally, and consider their impacts on microbiome homeostasis and health outcomes through a microbial ecology lens. In addition, we explore the concept of rewilding the human microbiome by reintroducing "missing microbes" from nonindustrialized societies and personalizing microbiome modulation to fit individual microbial profiles-highlighting several promising directions for future research. Ultimately, the advancements in sequencing technologies combined with innovative microbial therapies and personalized approaches herald a new era in medicine poised to address antibiotic resistance and improve health outcomes through targeted microbiome management.

Identifiants

pubmed: 39392836
doi: 10.1111/nyas.15237
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Canada Research Chairs
ID : 950-232131
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : PDF-402947
Organisme : Natural Sciences and Engineering Research Council of Canada
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 2023

Informations de copyright

© 2024 The Author(s). Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of The New York Academy of Sciences.

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Auteurs

Brendan A Daisley (BA)

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.

Emma Allen-Vercoe (E)

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.

Classifications MeSH