IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
11 Oct 2024
11 Oct 2024
Historique:
medline:
11
10
2024
pubmed:
11
10
2024
entrez:
11
10
2024
Statut:
ppublish
Résumé
Neutrophil subsets endowed with regulatory/suppressive properties are widely regarded as deleterious immune cells that can jeopardize antitumoral response and/or antimicrobial resistance. Here, we describe a sizeable fraction of neutrophils characterized by the expression of programmed death-ligand 1 (PD-L1) in biological fluids of humans and mice with severe viral respiratory infections (VRI). Biological and transcriptomic approaches indicated that VRI-driven PD-L1
Identifiants
pubmed: 39392875
doi: 10.1126/sciadv.adn3257
doi:
Substances chimiques
Interferon-gamma
82115-62-6
B7-H1 Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM