Anti-nociceptive effects of non-antibiotic derivatives of demeclocycline and doxycycline against formalin-induced pain stimulation.
Formalin-pain model
Microglia
Non-antibiotic tetracyclines
Pain
c-Fos
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
received:
27
03
2024
revised:
07
10
2024
accepted:
09
10
2024
medline:
12
10
2024
pubmed:
12
10
2024
entrez:
11
10
2024
Statut:
aheadofprint
Résumé
In previous studies, some tetracycline (TC) antibiotics showed potential as analgesic. We investigated here the analgesic activity of new non-antibiotic TC derivatives using the formalin-induced nociceptive pain model in adult C57BL/6 mice. Specifically, we tested the effects of i.p. injections of DDMC (5, 10, 20 mg.kg
Identifiants
pubmed: 39393668
pii: S0014-2999(24)00744-1
doi: 10.1016/j.ejphar.2024.177054
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
177054Informations de copyright
Copyright © 2024. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest P.P.M., R.R-V, E.D-B., L.F. and B.F. have filed patent applications for the use of non-antibiotic tetracycline derivatives for the treatment of Parkinson’s disease and related disorders.