Direct recognition of an intact foreign protein by an αβ T cell receptor.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 Oct 2024
11 Oct 2024
Historique:
received:
19
12
2021
accepted:
21
08
2024
medline:
12
10
2024
pubmed:
12
10
2024
entrez:
11
10
2024
Statut:
epublish
Résumé
αβ T cell receptors (αβTCRs) co-recognise antigens when bound to Major Histocompatibility Complex (MHC) or MHC class I-like molecules. Additionally, some αβTCRs can bind non-MHC molecules, but how much intact antigen reactivities are achieved remains unknown. Here, we identify an αβ T cell clone that directly recognises the intact foreign protein, R-phycoerythrin (PE), a multimeric (αβ)
Identifiants
pubmed: 39394178
doi: 10.1038/s41467-024-51897-3
pii: 10.1038/s41467-024-51897-3
doi:
Substances chimiques
Receptors, Antigen, T-Cell, alpha-beta
0
Phycoerythrin
11016-17-4
Complementarity Determining Regions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8816Informations de copyright
© 2024. The Author(s).
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