Differential gut microbiota composition in β-Thalassemia patients and its correlation with iron overload.
Iron overload
Microbiome
Thalassemia
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 Oct 2024
11 Oct 2024
Historique:
received:
03
07
2024
accepted:
04
10
2024
medline:
12
10
2024
pubmed:
12
10
2024
entrez:
11
10
2024
Statut:
epublish
Résumé
Recent research highlights the significant impact of the gut microbiota on health and disease. Thalassemia, a hereditary blood disorder, requires regular blood transfusions, leading to an accumulation of iron in the body. Such changes could potentially alter the intestinal microbiota, thereby increasing the susceptibility of thalassemic patients to infection. In this study, we analyzed the fecal microbiota of 70 non-transfusion-dependent (NTDT) β-thalassemia/HbE patients and 30 healthy controls. Our findings indicate that iron chelation intervention had no detectable effect on the microbiome profile of thalassemic patients. However, the cross-sectional analysis revealed that the bacterial diversity and community structure in patients were significantly less diverse and distinct compared to those of healthy subjects. Using reference frames, we were also able to demonstrate that bacterial taxa that are known to produce short chain fatty acids, from the genera Alistipes, Coprococcus, and Oscillospira, and those from the family Ruminococcaceae, were less prevalent in the patients. In contrast, bacterial taxa associated with an unhealthy gut, including the genus Clostridium and those from the families Fusobacteriaceae, Enterobacteriaceae, and Peptostrptococcaceae, were more prevalent in patients and found to be correlated with higher levels of ferritin. Collectively, these changes in the microbiota could be regarded as markers of raised ferritin levels, and therefore, awareness should be exercised as they could interfere, albeit indirectly, with the treatment of the co-morbidities of thalassemia.
Identifiants
pubmed: 39394230
doi: 10.1038/s41598-024-75456-4
pii: 10.1038/s41598-024-75456-4
doi:
Substances chimiques
Ferritins
9007-73-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23858Subventions
Organisme : Thailand Research Fund
ID : DPG6080003
Organisme : Thailand Research Fund
ID : DPG6080003
Organisme : Thailand Research Fund
ID : DPG6080003
Organisme : The Program Management Unit for Human Resources and Institution Development, Research and Innovation
ID : B05F630062
Organisme : The Program Management Unit for Human Resources and Institution Development, Research and Innovation
ID : B05F630062
Informations de copyright
© 2024. The Author(s).
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