Assessing vitamin E acetate as a proxy for E-cigarette additives in a realistic pulmonary surfactant model.
EVALI
Lung surfactant
Molecular dynamics simulation
Pulmonary surfactant
Vaping-associated pulmonary injury
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 Oct 2024
11 Oct 2024
Historique:
received:
11
06
2024
accepted:
03
10
2024
medline:
12
10
2024
pubmed:
12
10
2024
entrez:
11
10
2024
Statut:
epublish
Résumé
Additives in vaping products, such as flavors, preservatives, or thickening agents, are commonly used to enhance user experience. Among these, Vitamin E acetate (VEA) was initially thought to be harmless but has been implicated as the primary cause of e-cigarette or vaping product use-associated lung injury, a serious lung disease. In our study, VEA serves as a proxy for other e-cigarette additives. To explore its harmful effects, we developed an exposure system to subject a pulmonary surfactant (PSurf) model to VEA-rich vapor. Through detailed analysis and atomic-level simulations, we found that VEA tends to cluster into aggregates on the PSurf surface, inducing deformations and weakening its essential elastic properties, critical for respiratory cycle function. Apart from VEA, our experiments also indicate that propylene glycol and vegetable glycerin, widely used in e-liquid mixtures, or their thermal decomposition products, alter surfactant properties. This research provides molecular-level insights into the detrimental impacts of vaping product additives on lung health.
Identifiants
pubmed: 39394419
doi: 10.1038/s41598-024-75301-8
pii: 10.1038/s41598-024-75301-8
doi:
Substances chimiques
Vitamin E
1406-18-4
Pulmonary Surfactants
0
Propylene Glycol
6DC9Q167V3
Acetates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23805Subventions
Organisme : Human Frontier Science Program
ID : RGP0059/2019
Organisme : Human Frontier Science Program
ID : RGP0059/2019
Organisme : Human Frontier Science Program
ID : RGP0059/2019
Organisme : Research Council of Finland
ID : 331349, 336234, 346135
Organisme : Research Council of Finland
ID : 331349, 336234, 346135
Organisme : Research Council of Finland
ID : 331349, 336234, 346135
Organisme : Grantová Agentura České Republiky
ID : 21-19854S
Organisme : Grantová Agentura České Republiky
ID : 21-19854S
Organisme : Grantová Agentura České Republiky
ID : 21-19854S
Informations de copyright
© 2024. The Author(s).
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