Multi-channel portable odor delivery device for self-administered and rapid smell testing.


Journal

Communications engineering
ISSN: 2731-3395
Titre abrégé: Commun Eng
Pays: England
ID NLM: 9918523382506676

Informations de publication

Date de publication:
11 Oct 2024
Historique:
received: 14 03 2024
accepted: 30 09 2024
medline: 12 10 2024
pubmed: 12 10 2024
entrez: 11 10 2024
Statut: epublish

Résumé

To improve our understanding of the perception of odors, researchers are often required to undertake experimental procedures with users exposed to multiple odors in a variety of settings, including to diagnose smell loss in clinics and care homes. Existing smell tests are typically administered using multiple sniffing pens, manually presented to patients by a highly specialized nurse using a time-consuming and complex testing paradigm. Automated odor delivery devices, such as olfactometer systems, exist but are expensive, bulky and typically lab based, making them difficult to use for on the ground odor delivery. Here we have developed a portable, affordable, odor delivery device that can deliver 24 odors through individual channels with high temporal precision and without cross-contamination. The device allows for the rapid, flexible sequencing of odors via digital control using a mobile application and has been experimentally validated in the lab, as well as tested on patients. The design provides several advantages for investigating olfactory perception and offers the possibility that users can one day self-administer smell tests in a range of settings, including at home, allowing smell healthcare services to evolve and become part of a routine practice and self-care culture.

Identifiants

pubmed: 39394479
doi: 10.1038/s44172-024-00286-1
pii: 10.1038/s44172-024-00286-1
doi:

Types de publication

Journal Article

Langues

eng

Pagination

141

Subventions

Organisme : Hôpitaux Universitaires de Genève (Geneva University Hospitals)
ID : n/a

Informations de copyright

© 2024. The Author(s).

Références

Keller, A. & Malaspina, D. Hidden consequences of olfactory dysfunction: a patient report series. BMC Ear Nose Throat Disord. 13, 8 (2013).
doi: 10.1186/1472-6815-13-8
Kamrava, S. K. et al. A study of depression, partnership and sexual satisfaction in patients with post-traumatic olfactory disorders. Sci. Rep. 11, 20218 (2021).
doi: 10.1038/s41598-021-99627-9
Erskine, S. E. & Philpott, C. M. An unmet need: patients with smell and taste disorders. Clin. Otolaryngol. 45, 197–203 (2020).
doi: 10.1111/coa.13484
Shepherd, G. M. Smell images and the flavour system in the human brain. Nature 444, 316–321 (2006).
doi: 10.1038/nature05405
Hickson, M. Malnutrition and ageing. Postgrad. Med. J. 82, 2–8 (2006).
doi: 10.1136/pgmj.2005.037564
Carnemolla, S. E. et al. Olfactory dysfunction in frontotemporal dementia and psychiatric disorders: a systematic review. Neurosci. Biobehav. Rev. 118, 588–611 (2020).
doi: 10.1016/j.neubiorev.2020.08.002
Devanand, D. et al. Olfactory deficits predict cognitive decline and alzheimer dementia in an urban community. Neurology 84, 182–189 (2015).
doi: 10.1212/WNL.0000000000001132
Wilson, R. S. et al. Olfactory impairment in presymptomatic alzheimer’s disease. Ann. N. Y. Acad. Sci. 1170, 730–735 (2009).
doi: 10.1111/j.1749-6632.2009.04013.x
Morley, J. F. et al. Optimizing olfactory testing for the diagnosis of Parkinson’s disease: item analysis of the university of Pennsylvania smell identification test. npj Parkinson’s. Dis. 4, 2 (2018).
doi: 10.1038/s41531-017-0039-8
Schork, N. J. Personalized medicine: time for one-person trials. Nature 520, 609 (2015).
doi: 10.1038/520609a
Freedman, S., Lin, H. & Prince, J. Information technology and patient health: analyzing outcomes, populations, and mechanisms. Am. J. Health Econ. 4, 51–79 (2018).
doi: 10.1162/ajhe_a_00093
Hsieh, J. W., Keller, A., Wong, M., Jiang, R.-S. & Vosshall, L. B. Smell-s and smell-r: olfactory tests not influenced by odor-specific insensitivity or prior olfactory experience. Proc. Natl Acad. Sci. USA 114, 11275–11284 (2017).
doi: 10.1073/pnas.1711415114
Whitcroft, K. et al. Position paper on olfactory dysfunction: 2023. Rhinology 61, 1–108 (2023).
Hummel, T., Heilmann, S. & Hüttenbriuk, K.-B. Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope 112, 2076–2080 (2002).
doi: 10.1097/00005537-200211000-00031
Baskoy, K. et al. Is there any effect on smell and taste functions with levothyroxine treatment in subclinical hypothyroidism? PLoS ONE 11, e0149979 (2016).
doi: 10.1371/journal.pone.0149979
Ribeiro, J. C. et al. Cultural adaptation of the portuguese version of the “sniffin’sticks” smell test: reliability, validity, and normative data. PLoS ONE 11, e0148937 (2016).
doi: 10.1371/journal.pone.0148937
Lundström, J. N., Gordon, A. R., Alden, E. C., Boesveldt, S. & Albrecht, J. Methods for building an inexpensive computer-controlled olfactometer for temporally-precise experiments. Int. J. Psychophysiol. 78, 179–189 (2010).
doi: 10.1016/j.ijpsycho.2010.07.007
Vigouroux, M., Bertrand, B., Farget, V., Plailly, J. & Royet, J. A stimulation method using odors suitable for pet and fmri studies with recording of physiological and behavioral signals. J. Neurosci. Methods 142, 35–44 (2005).
doi: 10.1016/j.jneumeth.2004.07.010
Burton, S. D., Wipfel, M., Guo, M., Eiting, T. P. & Wachowiak, M. A novel olfactometer for efficient and flexible odorant delivery. Chem. Senses 44, 173–188 (2019).
doi: 10.1093/chemse/bjz005
Risso, P., Covarrubias Rodriguez, M., Bordegoni, M. & Gallace, A. Development and testing of a small-size olfactometer for the perception of food and beverages in humans. Front. Digit. Humanit. 5, 7 (2018).
doi: 10.3389/fdigh.2018.00007
Popp, R., Sommer, M., Muller, J. & Hajak, G. Olfactometry in fmri studies: odor presentation using nasal continuous positive airway pressure. Acta Neurobiol. Exp. 64, 171–176 (2004).
doi: 10.55782/ane-2004-1503
Feddes, J., Qu, G., Ouellette, C. & Leonard, J. Development of an eight-panelist single port, forced-choice, dynamic dilution olfactometer. Can. Biosyst. Eng. 43, 6–1 (2001).
Damuchali, A. M. & Guo, H. Evaluation of a field olfactometer in odour concentration measurement. Biosyst. Eng. 187, 239–246 (2019).
doi: 10.1016/j.biosystemseng.2019.09.007
Nieminen, V. et al. A compact olfactometer for IMS measurements and testing human perception. Int. J. Ion Mobil. Spec. 21, 71–78 (2018).
Johnson, B. N. & Sobel, N. Methods for building an olfactometer with known concentration outcomes. J. Neurosci. Methods 160, 231–245 (2007).
doi: 10.1016/j.jneumeth.2006.09.008
Hopper, R. et al. Multi-channel portable odor delivery device for self-administered and rapid smell testing data sets Apollo - University of Cambridge Repository https://doi.org/10.17863/CAM.111344 (2024).
Oleszkiewicz, A., Schriever, V., Croy, I., Hähner, A. & Hummel, T. Updated sniffin’sticks normative data based on an extended sample of 9139 subjects. Eur. Arch. Otorhinolaryngol. 276, 719–728 (2019).
doi: 10.1007/s00405-018-5248-1
Hummel, T., Sekinger, B., Wolf, S. R., Pauli, E. & Kobal, G. ‘sniffin’sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem. Senses 22, 39–52 (1997).
doi: 10.1093/chemse/22.1.39
Owen, C. M., Patterson, J. & Simpson, D. G. Development of a continuous respiration olfactometer for odorant delivery synchronous with natural respiration during recordings of brain electrical activity. IEEE Trans. Biomed. Eng. 49, 852–858 (2002).
doi: 10.1109/TBME.2002.800765
Bestgen, A.-K. et al. An extension of olfactometry methods: an expandable, fully automated, mobile, mri-compatible olfactometer. J. Neurosci. Methods 261, 85–96 (2016).
doi: 10.1016/j.jneumeth.2015.12.009

Auteurs

Richard Hopper (R)

OWidgets Ltd. - OW Smell Made Digital, London, E1 1DU, UK. richard@owidgets.co.uk.
Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK. richard@owidgets.co.uk.

Daniel Popa (D)

Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK. dp387@cam.ac.uk.

Emanuela Maggioni (E)

OWidgets Ltd. - OW Smell Made Digital, London, E1 1DU, UK. emanuela@owidgets.co.uk.
Department of Computer Science, University College London, London, NW1 2AE, UK. emanuela@owidgets.co.uk.

Devarsh Patel (D)

OWidgets Ltd. - OW Smell Made Digital, London, E1 1DU, UK.

Marianna Obrist (M)

Department of Computer Science, University College London, London, NW1 2AE, UK.

Basile Nicolas Landis (BN)

Rhinology-Olfactory Unit, Department of Otorhinolaryngology-Head and Neck Surgery, Geneva University Hospitals, Geneva, 1205, Switzerland.

Julien Wen Hsieh (JW)

Rhinology-Olfactory Unit, Department of Otorhinolaryngology-Head and Neck Surgery, Geneva University Hospitals, Geneva, 1205, Switzerland.

Florin Udrea (F)

Department of Engineering, University of Cambridge, Cambridge, CB3 0FA, UK.

Classifications MeSH