Comparison of treatment outcomes between slow coagulation transscleral cyclophotocoagulation and micropulse transscleral laser treatment.
Cyclophotocoagulation
Glaucoma
Micropulse laser
Surgery
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 Oct 2024
13 Oct 2024
Historique:
received:
17
06
2024
accepted:
03
10
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
13
10
2024
Statut:
epublish
Résumé
This study compared treatment outcomes of slow coagulation transscleral cyclophotocoagulation (SC-CPC, 65 eyes) and micropulse transscleral laser treatment (MPL, 134 eyes) in patients with medically uncontrolled glaucoma. Success was defined as achieving an intraocular pressure (IOP) of 6-21 mmHg with a ≥ 20% reduction from baseline, no reoperation for glaucoma, and no loss of light-perception vision. Visual acuity, number of glaucoma medication, corneal endothelial cell count, aqueous flare values, and complications were analyzed. At 12 months, mean IOP decreased from 32.2 ± 13.4 to 17.9 ± 8.3 mmHg in the SC-CPC group and from 26.4 ± 10.8 to 16.5 ± 6.8 mmHg in the MPL group. No significant changes were observed in visual acuity, medication count, or corneal endothelial cell count. Aqueous flare values increased immediately after the procedure and gradually decreased in both groups, with greater changes at 1 week significantly associated with greater IOP reduction (p < 0.05). Pupillary abnormalities were found in 5 eyes (4.5%) of the MPL group, with no severe complications. The 12-month success rates were 50.1% for SC-CPC and 38.2% for MPL (p = 0.131). Both SC-CPC and MPL effectively controlled IOP, with early postoperative aqueous flare values predicting treatment outcomes.
Identifiants
pubmed: 39397105
doi: 10.1038/s41598-024-75246-y
pii: 10.1038/s41598-024-75246-y
doi:
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
23944Informations de copyright
© 2024. The Author(s).
Références
Pastor, S. A. et al. Cyclophotocoagulation: a report by the American Academy of Ophthalmology. Ophthalmology. 108, 2130–2138. https://doi.org/10.1016/s0161-6420(01)00889-2 (2001).
doi: 10.1016/s0161-6420(01)00889-2
pubmed: 11713091
Dastiridou, A. I. et al. Cyclodestructive procedures in Glaucoma: a review of current and emerging options. Adv. Ther. 35, 2103–2127. https://doi.org/10.1007/s12325-018-0837-3 (2018).
doi: 10.1007/s12325-018-0837-3
pubmed: 30448885
pmcid: 6267695
Anand, N., Klug, E. & Nirappel, A. Solá-Del Valle, D. A review of Cyclodestructive procedures for the Treatment of Glaucoma. Semin Ophthalmol. 35, 261–275. https://doi.org/10.1080/08820538.2020.1810711 (2020).
doi: 10.1080/08820538.2020.1810711
pubmed: 32936725
Fong, Y. Y. Y., Wong, B. K. T., Li, F. C. H. & Young, A. L. A retrospective study of Transcleral Cyclophotocoagulation using the slow coagulation technique for the treatment of refractory Glaucoma. Semin Ophthalmol. 34, 398–402. https://doi.org/10.1080/08820538.2019.1638946 (2019).
doi: 10.1080/08820538.2019.1638946
pubmed: 31284800
Khodeiry, M. M., Lauter, A. J., Sayed, M. S., Han, Y. & Lee, R. K. Primary slow-coagulation transscleral cyclophotocoagulation laser treatment for medically recalcitrant neovascular glaucoma. Br. J. Ophthalmol. https://doi.org/10.1136/bjophthalmol-2021-319757 (2021).
doi: 10.1136/bjophthalmol-2021-319757
pubmed: 34848391
Khodeiry, M. M., Liu, X., Sheheitli, H., Sayed, M. S. & Lee, R. K. Slow Coagulation Transscleral Cyclophotocoagulation for Postvitrectomy patients with silicone oil-induced Glaucoma. J. Glaucoma. 30, 789–794. https://doi.org/10.1097/ijg.0000000000001893 (2021).
doi: 10.1097/ijg.0000000000001893
pubmed: 34049347
pmcid: 8404953
Khodeiry, M. M. et al. Treatment outcomes of slow Coagulation Transscleral Cyclophotocoagulation in Pseudophakic patients with medically uncontrolled Glaucoma. Am. J. Ophthalmol. 229, 90–99. https://doi.org/10.1016/j.ajo.2021.04.003 (2021).
doi: 10.1016/j.ajo.2021.04.003
pubmed: 33852906
Khodeiry, M. M., Liu, X. & Lee, R. K. Clinical outcomes of slow-coagulation continuous-wave transscleral cyclophotocoagulation laser for treatment of glaucoma. Curr. Opin. Ophthalmol. 33, 237–242. https://doi.org/10.1097/icu.0000000000000837 (2022).
doi: 10.1097/icu.0000000000000837
pubmed: 35200163
pmcid: 9530031
Elhusseiny, A. M., Khodeiry, M. M., Liu, X., Sayed, M. S. & Lee, R. K. Slow-coagulation transscleral cyclophotocoagulation laser treatment for medically uncontrolled secondary aphakic adult glaucoma. J. Glaucoma. https://doi.org/10.1097/ijg.0000000000002237 (2023).
doi: 10.1097/ijg.0000000000002237
pubmed: 37172013
pmcid: 10524893
Duerr, E. R. et al. Transscleral Diode Laser Cyclophotocoagulation: a comparison of slow coagulation and Standard Coagulation Techniques. Ophthalmol. Glaucoma. 1, 115–122. https://doi.org/10.1016/j.ogla.2018.08.007 (2018).
doi: 10.1016/j.ogla.2018.08.007
pubmed: 32632402
pmcid: 7337205
Sheheitli, H., Persad, P. J., Feuer, W. J., Sayed, M. S. & Lee, R. K. Treatment outcomes of primary Transscleral Cyclophotocoagulation. Ophthalmol. Glaucoma. 4, 472–481. https://doi.org/10.1016/j.ogla.2020.12.014 (2021).
doi: 10.1016/j.ogla.2020.12.014
pubmed: 33429109
Khodeiry, M. M., Liu, X., Sayed, M. S. & Lee, R. K. Outcomes of primary surgical treatment of medically recalcitrant post-keratoplasty glaucoma with transscleral cyclophotocoagulation. Eur. J. Ophthalmol. 11206721221149514 https://doi.org/10.1177/11206721221149514 (2023).
Aquino, M. C. et al. Micropulse versus continuous wave transscleral diode cyclophotocoagulation in refractory glaucoma: a randomized exploratory study. Clin. Exp. Ophthalmol. 43, 40–46. https://doi.org/10.1111/ceo.12360 (2015).
doi: 10.1111/ceo.12360
pubmed: 24811050
Williams, A. L. et al. Clinical efficacy and Safety Profile of Micropulse Transscleral Cyclophotocoagulation in Refractory Glaucoma. J. Glaucoma. 27, 445–449. https://doi.org/10.1097/ijg.0000000000000934 (2018).
doi: 10.1097/ijg.0000000000000934
pubmed: 29521718
Kaba, Q., Somani, S., Tam, E. & Yuen, D. The effectiveness and safety of Micropulse Cyclophotocoagulation in the treatment of ocular hypertension and Glaucoma. Ophthalmol. Glaucoma. 3, 181–189. https://doi.org/10.1016/j.ogla.2020.02.005 (2020).
doi: 10.1016/j.ogla.2020.02.005
pubmed: 32672613
Radhakrishnan, S. et al. Micropulse Cyclophotocoagulation: a Multicenter Study of Efficacy, Safety, and factors Associated with increased risk of complications. J. Glaucoma. 29, 1126–1131. https://doi.org/10.1097/ijg.0000000000001644 (2020).
doi: 10.1097/ijg.0000000000001644
pubmed: 32852377
Chamard, C., Bachouchi, A., Daien, V. & Villain, M. Efficacy, Safety, and Retreatment Benefit of Micropulse Transscleral Cyclophotocoagulation in Glaucoma. J. Glaucoma. 30, 781–788. https://doi.org/10.1097/ijg.0000000000001900 (2021).
doi: 10.1097/ijg.0000000000001900
pubmed: 34127629
Souissi, S. et al. An update on continuous-wave cyclophotocoagulation (CW-CPC) and micropulse transscleral laser treatment (MP-TLT) for adult and paediatric refractory glaucoma. Acta Ophthalmol. 99, e621–e653. https://doi.org/10.1111/aos.14661 (2021).
doi: 10.1111/aos.14661
pubmed: 33222409
de Kanadani, F. N., Dorairaj, F. C. L., Prata, T. S. & S. & Transscleral Cyclophotocoagulation: New perspectives for uncontrolled Glaucoma management. J. Curr. Glaucoma Pract. 17, 1–2. https://doi.org/10.5005/jp-journals-10078-1398 (2023).
doi: 10.5005/jp-journals-10078-1398
pubmed: 37228313
pmcid: 10203331
Nassiri, N. et al. Outcomes of microPulse transscleral laser therapy in eyes with prior glaucoma aqueous tube shunt. Graefes Arch. Clin. Exp. Ophthalmol. https://doi.org/10.1007/s00417-023-06119-9 (2023).
doi: 10.1007/s00417-023-06119-9
pubmed: 37247002
Zemba, M. et al. Micropulse vs. continuous wave transscleral cyclophotocoagulation in neovascular glaucoma. Exp. Ther. Med. 23, 278. https://doi.org/10.3892/etm.2022.11207 (2022).
doi: 10.3892/etm.2022.11207
pubmed: 35317447
pmcid: 8908348
Fili, S., Vastardis, I., Perdikakis, G. & Kohlhaas, M. Transscleral cyclophotocoagulation with MicroPulse
doi: 10.1007/s10792-021-02023-5
pubmed: 34596834
Bernardi, E. & Töteberg-Harms, M. MicroPulse Transscleral Laser Therapy demonstrates similar efficacy with a Superior and more favorable Safety Profile compared to continuous-Wave Transscleral Cyclophotocoagulation. J. Ophthalmol. 2022 (8566044). https://doi.org/10.1155/2022/8566044 (2022).
McKelvie, P. A. & Walland, M. J. Pathology of Cyclodiode laser: a series of nine enucleated eyes. Br. J. Ophthalmol. 86, 381–386. https://doi.org/10.1136/bjo.86.4.381 (2002).
doi: 10.1136/bjo.86.4.381
pubmed: 11914203
pmcid: 1771068
Liu, G. J., Mizukawa, A. & Okisaka, S. Mechanism of intraocular pressure decrease after contact transscleral continuous-wave nd:YAG laser cyclophotocoagulation. Ophthalmic Res. 26, 65–79. https://doi.org/10.1159/000267395 (1994).
doi: 10.1159/000267395
pubmed: 8196935
Sawa, M., Tsurimaki, Y., Tsuru, T. & Shimizu, H. New quantitative method to determine protein concentration and cell number in aqueous in vivo. Jpn J. Ophthalmol. 32, 132–142 (1988).
pubmed: 3054216
Tekeli, O. & Köse, H. C. Comparison of aqueous flare values after Micropulse Transscleral Laser Treatment and continuous Wave Transscleral Cyclophotocoagulation. Ocul Immunol. Inflamm. 31, 541–549. https://doi.org/10.1080/09273948.2022.2042315 (2023).
doi: 10.1080/09273948.2022.2042315
pubmed: 35522198
Cakir, I. et al. Anterior chamber laser flare photometry after diode laser cyclophotocoagulation. Photodiagnosis Photodyn Ther. 37, 102580. https://doi.org/10.1016/j.pdpdt.2021.102580 (2022).
doi: 10.1016/j.pdpdt.2021.102580
pubmed: 34648993
Kimura, A., Nakashima, K. I. & Inoue, T. Correlation between intraocular pressure reduction and anterior chamber aqueous flare after micropulse transscleral cyclophotocoagulation. BMC Ophthalmol. 21, 266. https://doi.org/10.1186/s12886-021-02012-3 (2021).
doi: 10.1186/s12886-021-02012-3
pubmed: 34182978
pmcid: 8240404
Gupta, S. et al. Outcomes of a combination of augmented MicroPulse and limited continuous Wave Cyclophotocoagulation in patients with refractory glaucoma. Graefes Arch. Clin. Exp. Ophthalmol. 260, 1583–1592. https://doi.org/10.1007/s00417-021-05436-1 (2022).
doi: 10.1007/s00417-021-05436-1
pubmed: 34694455
Grippo, T. M. et al. Evidence-based Consensus Guidelines Series for MicroPulse Transscleral Laser Therapy: Dosimetry and Patient Selection. Clin. Ophthalmol. 16, 1837–1846. https://doi.org/10.2147/opth.S365647 (2022).
doi: 10.2147/opth.S365647
pubmed: 35698599
pmcid: 9188391
Fang, C. E. H., Mathew, R. G., Khaw, P. T. & Henein, C. Corneal endothelial cell density loss after Glaucoma surgery alone or in combination with cataract surgery: a systematic review and Meta-analysis. Ophthalmology. 129, 841–855. https://doi.org/10.1016/j.ophtha.2022.03.015 (2022).
doi: 10.1016/j.ophtha.2022.03.015
pubmed: 35331751
Kuebler, A. G., Priglinger, S. & Reznicek, L. Micropulse Cyclophotocoagulation vs selective laser trabeculoplasty: effects on corneal endothelial cells and intraocular pressure. J. Curr. Glaucoma Pract. 17, 40–43. https://doi.org/10.5005/jp-journals-10078-1393 (2023).
doi: 10.5005/jp-journals-10078-1393
pubmed: 37228306
pmcid: 10203327
Makri, O. E., Plotas, P., Christopoulou, E. & Georgakopoulos, C. D. Effect of a single session of micropulse laser trabeculoplasty on corneal endothelial parameters. Clin. Exp. Optom. 103, 479–483. https://doi.org/10.1111/cxo.12968 (2020).
doi: 10.1111/cxo.12968
pubmed: 31618800