Nutritional deuterium depletion and health: a scoping review.
Cancer
Deutenomics
Diabetes
Health
Human deutenome project
Ketogenic diet
Metabolic water
Mitochondria
Nutrition
Journal
Metabolomics : Official journal of the Metabolomic Society
ISSN: 1573-3890
Titre abrégé: Metabolomics
Pays: United States
ID NLM: 101274889
Informations de publication
Date de publication:
13 Oct 2024
13 Oct 2024
Historique:
received:
05
06
2024
accepted:
18
09
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
13
10
2024
Statut:
epublish
Résumé
Large variations in fatty and amino acid natural The purpose of this scoping review is to examine health effects through deuterium homeostasis using deuterium-depleted water and/or a deuterium-depleted diet. We also aim to reveal health effects of nutritional, metabolic and exercise ketosis, i.e. complete mitochondrial fatty acid oxidation with the production of deuterium depleted (deupleted) metabolic water. A protocol process approach was used to retrieve current research in deuterium depletion according to the preferred reporting items protocol for systematic reviews and meta-analyses, extension for scoping reviews with checklist (PRISMA-ScR). Fifteen research articles were used. All retrieved articles were heterogenous in nature and additional themes did not evolve. Deuterium depletion was found to have beneficial health effects in the following conditions: cancer prevention, cancer treatment, depression, diabetes, long-term memory, anti-aging, and sports performance. Deutenomics is actively pursued in drug research and there are biomarker roles attributed to large natural variations with adaptive significance in biology. Even with limited data, consistent deuterium depletion can be seen across all conditions reviewed. More randomized control trials are recommended to confirm cause and effect for translationally and clinically informed integrative nutrition-based medical interventions.
Identifiants
pubmed: 39397213
doi: 10.1007/s11306-024-02173-4
pii: 10.1007/s11306-024-02173-4
doi:
Substances chimiques
Deuterium
AR09D82C7G
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
117Informations de copyright
© 2024. The Author(s).
Références
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