Association between cognitive reserve proxies and frailty phenotype: data from UK Biobank.
Cognitive function
Cognitive reserve
Frailty phenotype
UK Biobank
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
14 Oct 2024
14 Oct 2024
Historique:
received:
14
08
2024
accepted:
04
10
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
13
10
2024
Statut:
aheadofprint
Résumé
A potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored the cross-sectional association between cognitive reserve indicators and frailty phenotype. Data were obtained from the UK Biobank. We included 31,975 dementia-free participants aged ≥ 60 years (50.7% females, 2.2% frail) who completed a web-based cognitive assessment (fluid intelligence, working memory, visuospatial attention and processing speed, and executive functioning). Frailty was defined according to the Fried's phenotype (unintentional weight loss, exhaustion, low physical activity, slowness, and weakness). Participants meeting three or more criteria were classified as frail. Cognitive performance was compared between nonfrail and frail groups, and regression models were employed to analyze the associations between cognitive reserve proxies (education, skill level of occupation, social support, and multiple deprivation index (MDI)) and the likelihood of frailty. Frail and nonfrail groups significantly differed on cognitive function, with frail individuals demonstrating poorer performance on all cognitive functions (all p < .05) except fluid intelligence. Regression analysis showed that, after adjusting for age and sex, a lower educational level (odds ratio (OR) .797, 95% confidence interval (CI) .673-.944, p = .009), having maintained occupations with low cognitive requirements (OR .790, 95% CI .668-.936, p = .006), having less social support (OR .755, 95% CI .631-.903, p = .002), and living in a region with a high rate of multiple deprivation (OR 1.025, 95% CI 1.019-1.031, p < .001), significantly increased the probability of experiencing frailty. Our findings support the relationship between declined cognitive functions and frailty emphasizing the importance of implementing public health measures to enhance cognitive reserve.
Identifiants
pubmed: 39397220
doi: 10.1007/s11357-024-01382-y
pii: 10.1007/s11357-024-01382-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : Grant PID2020-113788RB-I00
Organisme : Ministerio de Educación, Cultura y Deporte
ID : PRX19/00353
Organisme : Xunta de Galicia
ID : ED431B 2022/16
Informations de copyright
© 2024. The Author(s), under exclusive licence to American Aging Association.
Références
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62. https://doi.org/10.1016/S0140-6736(12)62167-9 .
doi: 10.1016/S0140-6736(12)62167-9
pubmed: 23395245
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):146–57. https://doi.org/10.1093/gerona/56.3.m146 .
doi: 10.1093/gerona/56.3.m146
Morley JE, Vellas B, Abellan van Kan G, Anker SD, Bauer JM, Bernabei R, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392–7. https://doi.org/10.1016/j.jamda.2013.03.022 .
doi: 10.1016/j.jamda.2013.03.022
pubmed: 23764209
pmcid: 4084863
Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62(7):722–7. https://doi.org/10.1093/gerona/62.7.722 .
doi: 10.1093/gerona/62.7.722
pubmed: 17634318
Robinson TL, Gogniat MA, Miller LS. Frailty and cognitive function in older adults: a systematic review and meta-analysis of cross-sectional studies. Neuropsychol Rev. 2022;32(2):274–93. https://doi.org/10.1007/s11065-021-09497-1 .
doi: 10.1007/s11065-021-09497-1
pubmed: 33886024
Stern Y. Cognitive reserve in ageing and Alzheimer’s disease. Lancet Neurol. 2012;11(11):1006–12. https://doi.org/10.1016/S1474-4422(12)70191-6 .
doi: 10.1016/S1474-4422(12)70191-6
pubmed: 23079557
pmcid: 3507991
Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc. 2002;8(3):448–60. https://doi.org/10.1017/S1355617702813248 .
doi: 10.1017/S1355617702813248
pubmed: 11939702
Brigola AG, Alexandre TDS, Inouye K, Yassuda MS, Pavarini SCI, Mioshi E. Limited formal education is strongly associated with lower cognitive status, functional disability and frailty status in older adults. Dement Neuropsychol. 2019;13(2):216–24. https://doi.org/10.1590/1980-57642018dn13-020011 .
doi: 10.1590/1980-57642018dn13-020011
pubmed: 31285797
pmcid: 6601310
Stern Y, Arenaza-Urquijo EM, Bartrés-Faz D, Belleville S, Cantilon M, Chetelat G, et al. Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance. Alzheimers Dement. 2020;16(9):1305–11. https://doi.org/10.1016/j.jalz.2018.07.219 .
doi: 10.1016/j.jalz.2018.07.219
pubmed: 30222945
Sardella A, Catalano A, Lenzo V, Bellone F, Corica F, Quattropani MC, et al. Association between cognitive reserve dimensions and frailty among older adults: a structured narrative review. Geriatr Gerontol Int. 2020;20(11):1005–23. https://doi.org/10.1111/ggi.14040 .
doi: 10.1111/ggi.14040
pubmed: 32998186
Quattropani MC, Sardella A, Morgante F, Ricciardi L, Alibrandi A, Lenzo V, Catalano A, Squadrito G, Basile G. Impact of Cognitive Reserve and Premorbid IQ on Cognitive and Functional Status in Older Outpatients. Brain Sci. 2021;11(7):824. https://doi.org/10.3390/brainsci11070824 .
doi: 10.3390/brainsci11070824
pubmed: 34206258
pmcid: 8301973
Zijlmans JL, Lamballais S, Lahousse L, Vernooij MW, Ikram MK, Ikram MA, et al. The interaction of cognitive and brain reserve with frailty in the association with mortality: an observational cohort study. Lancet Healthy Longev. 2021;2(4):e194-201. https://doi.org/10.1016/S2666-7568(21)00028-3 .
doi: 10.1016/S2666-7568(21)00028-3
pubmed: 36098120
Jia F, Liu H, Xu K, Sun J, Zhu Z, Shan J, et al. Mediating effects of cognitive reserve on the relationship between frailty and cognition in older people without dementia. Eur Geriatr Med. 2022;13(6):1317–25. https://doi.org/10.1007/s41999-022-00703-8 .
doi: 10.1007/s41999-022-00703-8
pubmed: 36272064
Kelaiditi E, Cesari M, Canevelli M, Abellan van Kan G, Ousset P-J, Gillette-Guyonnet S, et al. Cognitive frailty: rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group. J Nutr Health Aging. 2013;17(9):726–34. https://doi.org/10.1007/s12603-013-0367-2 .
doi: 10.1007/s12603-013-0367-2
pubmed: 24154642
Navarro-Pardo E, Facal D, Campos-Magdaleno M, Pereiro AX, Juncos-Rabadán O. Prevalence of cognitive frailty, do psychosocial-related factors matter? Brain Sci. 2020;10(12):1–9. https://doi.org/10.3390/brainsci10120968 .
doi: 10.3390/brainsci10120968
Fawns-Ritchie C, Deary IJ. Reliability and validity of the UK Biobank cognitive tests. PLoS One. 2020;15(4):e0231627. https://doi.org/10.1371/journal.pone.0231627 .
doi: 10.1371/journal.pone.0231627
pubmed: 32310977
pmcid: 7170235
Hanlon P, Nicholl BI, Jani BD, Lee D, McQueenie R, Mair FS. Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants. Lancet Public Health. 2018;3(7):e323–32. https://doi.org/10.1016/S2468-2667(18)30091-4 .
doi: 10.1016/S2468-2667(18)30091-4
pubmed: 29908859
pmcid: 6028743
International Labour Organization_ESCO (EU). International Standard Classification of Occupations - ISCO-08_Volume 1. Geneva: 2012.
Lloyd CD, Norman PD, McLennan D. Deprivation in England, 1971–2020. Appl Spat Anal Policy. 2023;16(1):461–84. https://doi.org/10.1007/s12061-022-09486-8 .
doi: 10.1007/s12061-022-09486-8
pubmed: 36405332
Lövdén M, Fratiglioni L, Glymour MM, Lindenberger U, Tucker-Drob EM. Education and cognitive functioning across the life span. Psychol Sci Public Interest. 2020;21(1):6–41. https://doi.org/10.1177/1529100620920576 .
doi: 10.1177/1529100620920576
pubmed: 32772803
pmcid: 7425377
Kojima G, Taniguchi Y, Iliffe S, Walters K. Frailty as a predictor of Alzheimer disease, vascular dementia, and all dementia among community-dwelling older people: a systematic review and meta-analysis. J Am Med Dir Assoc. 2016;17(10):881–8. https://doi.org/10.1016/j.jamda.2016.05.013 .
doi: 10.1016/j.jamda.2016.05.013
pubmed: 27324809
Petermann-Rocha F, Lyall DM, Gray SR, Esteban-Cornejo I, Quinn TJ, Ho FK, et al. Associations between physical frailty and dementia incidence: a prospective study from UK Biobank. Lancet Healthy Longev. 2020;1(2):e58–68. https://doi.org/10.1016/S2666-7568(20)30007-6 .
doi: 10.1016/S2666-7568(20)30007-6
pubmed: 36094146
Lorenzo-López L, Blanco-Fandiño J, Cibeira N, Buján A, López-López R, Maseda A, et al. Clinical and neuropsychological correlates of prefrailty syndrome. Front Med (Lausanne). 2020;7:609359. https://doi.org/10.3389/fmed.2020.609359 .
doi: 10.3389/fmed.2020.609359
pubmed: 33240913
Borda MG, Soennesyn H, Steves CJ, Osland Vik-Mo A, Pérez-Zepeda MU, Aarsland D. Frailty in older adults with mild dementia: dementia with Lewy bodies and Alzheimer’s disease. Dement Geriatr Cogn Dis Extra. 2019;9(1):176–83. https://doi.org/10.1159/000496537 .
doi: 10.1159/000496537
Robertson DA, Savva GM, Kenny RA. Frailty and cognitive impairment-a review of the evidence and causal mechanisms. Ageing Res Rev. 2013;12(4):840–51. https://doi.org/10.1016/j.arr.2013.06.004 .
doi: 10.1016/j.arr.2013.06.004
pubmed: 23831959
Godin J, Armstrong JJ, Rockwood K, Andrew MK. Dynamics of frailty and cognition after age 50: why it matters that cognitive decline is mostly seen in old age. J Alzheimers Dis. 2017;58(1):231–42. https://doi.org/10.3233/JAD-161280 .
doi: 10.3233/JAD-161280
pubmed: 28387672
Xue QL, Buta B, Ma L, Ge M, Carlson M. Integrating frailty and cognitive phenotypes: why, how, now what? Curr Geriatr Rep. 2019;8(2):97–106. https://doi.org/10.1007/s13670-019-0279-z .
doi: 10.1007/s13670-019-0279-z
pubmed: 31815092
pmcid: 6897328
de Fabrício DM, Chagas MHN, Diniz BS. Frailty and cognitive decline. Transl Res. 2020;221:58–64. https://doi.org/10.1016/j.trsl.2020.01.002 .
doi: 10.1016/j.trsl.2020.01.002
pubmed: 32045578
Ticinesi A, Tana C, Nouvenne A, Prati B, Lauretani F, Meschi T. Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review. Clin Interv Aging. 2018;13:1497–511. https://doi.org/10.2147/CIA.S139163 .
doi: 10.2147/CIA.S139163
pubmed: 30214170
pmcid: 6120508
Kocagoncu E, Nesbitt D, Emery T, Hughes LE, Henson RN, Rowe JB. Neurophysiological and brain structural markers of cognitive frailty differ from Alzheimer’s disease. J Neurosci. 2022;42(7):1362–73. https://doi.org/10.1523/JNEUROSCI.0697-21.2021 .
doi: 10.1523/JNEUROSCI.0697-21.2021
pubmed: 35012965
pmcid: 8883844
Brigola AG, Rossetti ES, dos Santos BR, Neri AL, Zazzetta MS, Inouye K, et al. Relationship between cognition and frailty in elderly: a systematic review. Dement Neuropsychol. 2015;9(2):110–9. https://doi.org/10.1590/1980-57642015DN92000005 .
doi: 10.1590/1980-57642015DN92000005
pubmed: 29213952
pmcid: 5619349
Canevelli M, Cesari M, Van Kan GA. Frailty and cognitive decline: how do they relate? Curr Opin Clin Nutr Metab Care. 2015;18(1):43–50. https://doi.org/10.1097/MCO.0000000000000133 .
doi: 10.1097/MCO.0000000000000133
pubmed: 25405314
Searle SD, Rockwood K. Frailty and the risk of cognitive impairment. Alzheimers Res Ther. 2015;7(1):54. https://doi.org/10.1186/s13195-015-0140-3 .
doi: 10.1186/s13195-015-0140-3
pubmed: 26240611
pmcid: 4523015
Alexandre TDS, Corona LP, Nunes DP, Santos JLF, Duarte YAO, Lebrão ML. Similarities among factors associated with components of frailty in elderly: SABE study. J Aging Health. 2014;26(3):441–57. https://doi.org/10.1177/0898264313519818 .
doi: 10.1177/0898264313519818
pubmed: 24505067
Gallucci M, Mazzarolo AP, Focella L, Piovesan C, Mazzetto M, Ramigni M, et al. ’Camminando e Leggendo... “Ricordo” (Walking and Reading... i Remember): prevention of frailty through the promotion of physical activity and reading in people with mild cognitive impairment. Results from the TREDEM Registry. J Alzheimers Dis. 2020;77(2):689–99. https://doi.org/10.3233/JAD-200542 .
doi: 10.3233/JAD-200542
pubmed: 32741832
Niederstrasser NG, Rogers NT, Bandelow S. Determinants of frailty development and progression using a multidimensional frailty index: evidence from the English Longitudinal Study of Ageing. PLoS One. 2019;14(10):e0223799. https://doi.org/10.1371/journal.pone.0223799 .
doi: 10.1371/journal.pone.0223799
pubmed: 31665163
pmcid: 6821067
Hoogendijk EO, van Hout HPJ, Heymans MW, van der Horst HE, Frijters DHM, Broese van Groenou MI, et al. Explaining the association between educational level and frailty in older adults: results from a 13-year longitudinal study in the Netherlands. Ann Epidemiol. 2014;24(7):538-544.e2. https://doi.org/10.1016/j.annepidem.2014.05.002 .
doi: 10.1016/j.annepidem.2014.05.002
pubmed: 24935466
Iavicoli I, Leso V, Cesari M. The contribution of occupational factors on frailty. Arch Gerontol Geriatr. 2018;75:51–8. https://doi.org/10.1016/j.archger.2017.11.010 .
doi: 10.1016/j.archger.2017.11.010
pubmed: 29190544
Lane AP, Windsor TD, Andel R, Luszcz MA. Is occupational complexity associated with cognitive performance or decline? Results from the Australian Longitudinal Study of Ageing. Gerontology. 2017;63(6):550–9. https://doi.org/10.1159/000475559 .
doi: 10.1159/000475559
pubmed: 28511173
Ihle A, Gouveia ÉR, Gouveia BR, Freitas DL, Jurema J, Odim AP, et al. The relation of education, occupation, and cognitive activity to cognitive status in old age: The role of physical frailty. Int Psychogeriatr. 2017;29(9):1469–74. https://doi.org/10.1017/S1041610217000795 .
doi: 10.1017/S1041610217000795
pubmed: 28539130
Sun J, Kong X, Li H, Chen J, Yao Q, Li H, et al. Does social participation decrease the risk of frailty? Impacts of diversity in frequency and types of social participation on frailty in middle-aged and older populations. BMC Geriatr. 2022;22(1):553. https://doi.org/10.1186/s12877-022-03219-9 .
doi: 10.1186/s12877-022-03219-9
pubmed: 35778684
pmcid: 9250233
Gale CR, Westbury L, Cooper C. Social isolation and loneliness as risk factors for the progression of frailty: the English Longitudinal Study of Ageing. Age Ageing. 2018;47(3):392–7. https://doi.org/10.1093/ageing/afx188 .
doi: 10.1093/ageing/afx188
pubmed: 29309502
Hoogendijk EO, Smit AP, van Dam C, Schuster NA, de Breij S, Holwerda TJ, et al. Frailty combined with loneliness or social isolation: an elevated risk for mortality in later life. J Am Geriatr Soc. 2020;68(11):2587–93. https://doi.org/10.1111/jgs.16716 .
doi: 10.1111/jgs.16716
pubmed: 32700319
pmcid: 7689758
Pitter JG, Zemplényi A, Babarczy B, Németh B, Kaló Z, Vokó Z. Frailty prevalence in 42 European countries by age and gender: development of the SHARE Frailty Atlas for Europe. Geroscience. 2024;46(2):1807–24. https://doi.org/10.1007/s11357-023-00975-3 .
doi: 10.1007/s11357-023-00975-3
pubmed: 37855861
Yegla B, Foster TC. Operationally defining cognitive reserve genes. Neurobiol Aging. 2022;110:96–105. https://doi.org/10.1016/j.neurobiolaging.2021.08.015 .
doi: 10.1016/j.neurobiolaging.2021.08.015
pubmed: 34565615
Gobbens RJJ, Luijkx KG, Wijnen-Sponselee MT, Schols JMGA. Towards an integral conceptual model of frailty. J Nutr Health Aging. 2010;14(3):175–81. https://doi.org/10.1007/s12603-010-0045-6 .
doi: 10.1007/s12603-010-0045-6
pubmed: 20191249