Ruthenium-catalyzed electrochemical C-H activation of benzamidine hydrochlorides with internal alkynes for the synthesis of 1-aminoisoquinolines.

A constant current electrochemical approach for the synthesis of 1-aminoisoquinoline derivatives through the Ru(II)-catalyzed annulation of benzamidine hydrochlorides with alkynes is reported herein. This method produces good yields of naphthyridine-based compounds