N-alkylation of amines for the synthesis of potential antiviral agents: A structural modification approach.

Chloroquine Drug synthesis Molecular docking Pharmacokinetic properties

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
15 Oct 2024
Historique:
received: 04 07 2024
revised: 26 09 2024
accepted: 26 09 2024
medline: 14 10 2024
pubmed: 14 10 2024
entrez: 14 10 2024
Statut: epublish

Résumé

The threat of emerging viral outbreaks has increased the need for fast and effective development of therapeutics against emerging pathogens. One approach is to modify the structure of existing therapeutic agents to achieve the desired antiviral properties. Here, we attempted to synthesize a new antiviral compound by modifying the structure of chloroquine using the

Identifiants

pubmed: 39397970
doi: 10.1016/j.heliyon.2024.e38587
pii: S2405-8440(24)14618-X
pmc: PMC11470537
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e38587

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Nadia Arrousse (N)

School of Science and Engineering, Al Akhawayn University in Ifrane, Hassan II avenue, 53000 Ifrane, Morocco.
Laboratory of Engineering, Electrochemistry, Modelling and Environment (LIEME), Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez, Morocco.

Elyor Berdimurodov (E)

Faculty of Chemistry, National University of Uzbekistan, Tashkent, 100034, Uzbekistan.
Physics and Chemistry, Western Caspian University, AZ-1001, Baku, Azerbaijan.
University of Tashkent for Applied Sciences, Str. Gavhar 1, 100149, Tashkent, Uzbekistan.
Physics and Chemistry, Tashkent Institute of Irrigation and Agricultural Mechanization Engineers" National Research University, 100000, Tashkent, Uzbekistan.

Mariia Bogacheva (M)

Viral Zone Research Unit, Faculty of Medicine, University of Helsinki, Finland.

Fathiah Zakham (F)

Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland.

Soukaina Esslali (S)

Laboratory of Chemistry-Biology Applied to the Environment, Chemistry Department, Faculty of Sciences, Moulay-Ismail University, B.P. 11201, Zitoune, Meknes, Morocco.

Sghir El Kadiri (S)

Laboratory of Applied Chemistry & Environment (LCAE), Faculty of Science, Mohammed First University, Oujda, Morocco.

Mustapha Taleb (M)

Laboratory of Engineering, Electrochemistry, Modelling and Environment (LIEME), Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez, Morocco.

Olli Vapalahti (O)

Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland.

Classifications MeSH