N-alkylation of amines for the synthesis of potential antiviral agents: A structural modification approach.
Chloroquine
Drug synthesis
Molecular docking
Pharmacokinetic properties
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
15 Oct 2024
15 Oct 2024
Historique:
received:
04
07
2024
revised:
26
09
2024
accepted:
26
09
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
14
10
2024
Statut:
epublish
Résumé
The threat of emerging viral outbreaks has increased the need for fast and effective development of therapeutics against emerging pathogens. One approach is to modify the structure of existing therapeutic agents to achieve the desired antiviral properties. Here, we attempted to synthesize a new antiviral compound by modifying the structure of chloroquine using the
Identifiants
pubmed: 39397970
doi: 10.1016/j.heliyon.2024.e38587
pii: S2405-8440(24)14618-X
pmc: PMC11470537
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e38587Informations de copyright
© 2024 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.