Recent Trends in Therapeutic Drug Monitoring of Peptide Antibiotics.

capillary electrophoresis clinical outcomes liquid chromatography peptide antibiotics therapeutic drug monitoring

Journal

Journal of separation science
ISSN: 1615-9314
Titre abrégé: J Sep Sci
Pays: Germany
ID NLM: 101088554

Informations de publication

Date de publication:
Oct 2024
Historique:
revised: 17 09 2024
received: 04 08 2024
accepted: 19 09 2024
medline: 14 10 2024
pubmed: 14 10 2024
entrez: 14 10 2024
Statut: ppublish

Résumé

Antimicrobial peptides take a specific position in the field of antibiotics (ATBs), however, from a large number of available molecules only a few of them were approved and are used in clinics. These therapeutic modalities play a crucial role in the management of diseases caused by multidrug-resistant bacterial pathogens and represent the last-line therapy for bacterial infections. Therefore, there is a demand for a rationale use of such ATBs based on optimization of the dosing strategy to minimize the risk of resistance and ensure the sustainable efficacy of the drug in real clinical practice. Therapeutic drug monitoring, as a measurement of drug concentration in the body fluids or tissues, results in the optimization of the patient´s medication and therapy outcome. This strategy is beneficial and could result in tailored therapy for different types of infection and the prolongation of the use and efficacy of ATBs in hospitals. This review paper provides an actual overview of approved antimicrobial peptides used in clinical practice and covers current trends in their analysis by convenient and advanced methodologies used for their identification and/or quantitation in biological matrices for therapeutic drug monitoring purposes. Special emphasis is given to the methods with perspective clinical outcomes.

Identifiants

pubmed: 39400453
doi: 10.1002/jssc.202400583
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antimicrobial Peptides 0
Peptides 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202400583

Subventions

Organisme : Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
ID : VEGA. 1/0302/24

Informations de copyright

© 2024 Wiley‐VCH GmbH.

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Auteurs

Zuzana Kilianova (Z)

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovak Republic.

Ivana Cizmarova (I)

Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovak Republic.

Miroslava Spaglova (M)

Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovak Republic.

Juraj Piestansky (J)

Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovak Republic.
Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovak Republic.
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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