Protein Nanoparticles for Targeted SARS-CoV-2 Trapping and Neutralization.
SARS‐CoV‐2
SARS‐CoV‐2 trapping
antiviral nanomaterials
coiled coil protein nanoparticles
viral neutralization
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
14 Oct 2024
14 Oct 2024
Historique:
revised:
27
09
2024
received:
04
09
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
14
10
2024
Statut:
aheadofprint
Résumé
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to challenge global health despite widespread vaccination efforts, underscoring the need for innovative strategies to combat emerging infectious diseases effectively. Herein, LCB1-NPs and LCB3-NPs are engineered as a novel class of protein-only nanoparticles formed through coiled coil-driven self-assembly and tailored to interact specifically with the SARS-CoV-2 spike protein. The multivalency of LCB1-NPs and LCB3-NPs offers a strategy for efficiently targeting and neutralizing SARS-CoV-2 both in solution and when immobilized on surfaces. It is demonstrated that LCB1-NPs and LCB3-NPs bind to the SARS-CoV-2 spike protein's receptor-binding domain (RBD) with high affinity, effectively blocking the entry of SARS-CoV-2 virus-like particles into angiotensin-converting enzyme 2 (ACE2)-coated human cells. The cost-effectiveness, scalability, and straightforward production process of these protein nanoparticles make them suitable for developing novel anti-viral materials. Accordingly, it is shown how these nanostructures can be packed into columns to build up economic and highly potent trapping devices for SARS-CoV-2 adsorption.
Identifiants
pubmed: 39400473
doi: 10.1002/adhm.202402744
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2402744Subventions
Organisme : Spanish Ministry of Science and Innovation
ID : PID2022-137963OB-I00
Organisme : Spanish Ministry of Science and Innovation
ID : FPU20/02897
Organisme : Spanish Ministry of Science and Innovation
ID : IJC2019-041039-I
Organisme : Spanish Ministry of Science and Innovation
ID : PID2022-139271OB-I00
Organisme : Spanish Ministry of Science and Innovation
ID : CB21/13/00063
Organisme : Fundació la Marató de TV3
ID : 202120-30-31-32
Informations de copyright
© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.
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