Molecular Epidemiology and AMR Perspective of Diarrhoeagenic Escherichia coli in Africa: A Systematic Review and Meta-analysis.

Africa Antimicrobial resistance Diarrhoeagenic Escherichia coli Food and water-borne diseases

Journal

Journal of epidemiology and global health
ISSN: 2210-6014
Titre abrégé: J Epidemiol Glob Health
Pays: Switzerland
ID NLM: 101592084

Informations de publication

Date de publication:
14 Oct 2024
Historique:
received: 17 06 2024
accepted: 05 09 2024
medline: 14 10 2024
pubmed: 14 10 2024
entrez: 14 10 2024
Statut: aheadofprint

Résumé

Diarrhoeagenic Escherichia coli (DEC) persistently challenges public health in Africa, contributing substantially to the diarrhoeal disease burden. This systematic review and meta-analysis illuminate the distribution and antimicrobial resistance (AMR) patterns of DEC pathotypes across the continent. The review selectively focused on pathotype-specific studies reporting prevalence and/or AMR of human-derived DEC pathotypes from African nations, excluding data from extra-intestinal, animal, and environmental sources and studies focused on drug and mechanism experiments. Pertinent studies were retrieved from SCOPUS, PubMed, and EBSCOhost, processed with Covidence, and screened in alignment with PRISMA guidelines. The reviewed studies were predominantly hospital-based (80%) and paediatric-focused (91%), with a meagre 4.4% documenting DEC outbreaks. Seven DEC pathotypes were discerned, with Enteroaggregative E. coli (EAEC) being notably prevalent (43%, 95% CI 30-55%) and Enteroinvasive E. coli (EIEC) least prevalent (24%, 95% CI 17-32%). Identified non-susceptibilities were noted against essential antibiotics including ciprofloxacin, ceftriaxone, and ampicillin, while instances of carbapenem and Extended-Spectrum ß-Lactamase (ESBL) resistance were scarce. Despite sporadic data on DEC prevalence and AMR in Africa, particularly in community settings, a palpable gap remains in real-time outbreak surveillance and comprehensive data documentation. Augmenting surveillance and embracing advancements in molecular/genomic characterisation techniques are crucial to precisely discerning DEC's actual impact and resistance continuum in Africa.

Identifiants

DOI: 10.1007/s44197-024-00301-w PMID: 39400654
pubmed: 39400654
doi: 10.1007/s44197-024-00301-w
pii: 10.1007/s44197-024-00301-w
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

John Bosco Kalule (JB)

Makerere University, College of Veterinary Medicine Animal Resources and Biosecurity (CoVAB), Biotechnical and Diagnostic Sciences, Kampala, Uganda. kaluleb@gmail.com.

Linda A Bester (LA)

Biomedical Resource Unit, College of Health Sciences, University of KwaZulu-Natal ZA, Westville, South Africa.
Department of Biochemistry and Microbiology, Faculty of Science, Engineering and Agriculture, University of Venda, Limpopo, South Africa.

Daniel L Banda (DL)

Department of Medical Laboratory Sciences, School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Mzimba, Malawi.

Firehiwot Abera Derra (FA)

Food Safety and Food Microbiology National Reference Laboratory, Food Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

Chisomo Msefula (C)

Africa Centres for Disease Control and Prevention, African Union, Addis Ababa, Ethiopia.
Kamuzu University of Health Sciences, Blantyre, Malawi.

Anthony M Smith (AM)

Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.
Centre for Enteric Diseases, Division of the National Health Laboratory Service, National Institute for Communicable Diseases, Johannesburg, South Africa.
Department of Medical Microbiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Abraham Ajayi (A)

Molecular Biology and Biotechnology Department, Nigerian Institute of Medical Research (NIMR), Yaba Lagos, Nigeria.

Happiness Kumburu (H)

Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Geoffrey Kwenda (G)

Department of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, Zambia.

Kaunda Yamba (K)

University Teaching Hospitals, Lusaka, Zambia.
Zambia National Public Health Institute, Lusaka, Zambia.

John Mwaba (J)

Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia.
Institute of Basic and Biomedical Sciences, Levy Mwanawasa Medical University, Lusaka, Zambia.

Yasmina J Fakim (YJ)

University of Mauritius, Reduit, Mauritius.

Nyasha Sithole (N)

Africa CDC, Addis Ababa, Ethiopia.

Aquillah M Kanzi (AM)

African Society for Laboratory Medicine (ASLM), Johannesburg, South Africa.

Patrick M K Njage (PMK)

Research Group for Genomic Epidemiology, National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.

Francis Chikuse (F)

Africa Centres for Disease Control and Prevention, African Union, Addis Ababa, Ethiopia.
Kamuzu University of Health Sciences, Blantyre, Malawi.

Sofonias K Tessema (SK)

Africa Centres for Disease Control and Prevention, African Union, Addis Ababa, Ethiopia.
Kamuzu University of Health Sciences, Blantyre, Malawi.

Stella I Smith (SI)

Molecular Biology and Biotechnology Department, Nigerian Institute of Medical Research (NIMR), Yaba Lagos, Nigeria.

Ebenezer Foster-Nyarko (E)

Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.
Centre for Enteric Diseases, Division of the National Health Laboratory Service, National Institute for Communicable Diseases, Johannesburg, South Africa.

Classifications MeSH