Microfluidic-SERS sensing system based on dual signal amplification and aptamer for gastric cancer detection.
Aptamers, Nucleotide
/ chemistry
Stomach Neoplasms
/ diagnosis
Humans
Spectrum Analysis, Raman
/ methods
Gold
/ chemistry
Limit of Detection
Matrix Metalloproteinase 9
/ analysis
Interleukin-6
/ analysis
Metal Nanoparticles
/ chemistry
DNA, Single-Stranded
/ chemistry
Biosensing Techniques
/ methods
Microfluidic Analytical Techniques
/ instrumentation
Aptamer
Biomarker
Gastric cancer
Microfluidic chip
SERS
Journal
Mikrochimica acta
ISSN: 1436-5073
Titre abrégé: Mikrochim Acta
Pays: Austria
ID NLM: 7808782
Informations de publication
Date de publication:
14 Oct 2024
14 Oct 2024
Historique:
received:
08
07
2024
accepted:
08
10
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
14
10
2024
Statut:
epublish
Résumé
Studies have found that matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) play an important role in tumorigenesis. In order to detect MMP-9 and IL-6 concentrations with high sensitivity and specificity, an efficient microfluidic-SERS sensing system was prepared based on surface-enhanced Raman scattering (SERS). The aptamer recognition-release mechanism and the dual signal amplification strategy were applied in the sensing system. The sensor system was developed using two kinds of nanomaterials with excellent SERS properties, namely gold-coated iron tetroxide particles (Fe
Identifiants
pubmed: 39400726
doi: 10.1007/s00604-024-06760-z
pii: 10.1007/s00604-024-06760-z
doi:
Substances chimiques
Aptamers, Nucleotide
0
Gold
7440-57-5
Matrix Metalloproteinase 9
EC 3.4.24.35
Interleukin-6
0
DNA, Single-Stranded
0
MMP9 protein, human
EC 3.4.24.35
IL6 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
668Subventions
Organisme : Yangzhou Social Development fund
ID : YZ2022089
Organisme : Key Medical Research Projects of Yangzhou Health Commission
ID : 2023-1-04
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
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