The influence of non-cancer-related risk factors on the development of cancer-related lymphedema: a rapid review.
Risk factors
Risk models
Secondary lymphedema
Social determinants of health
Journal
Medical oncology (Northwood, London, England)
ISSN: 1559-131X
Titre abrégé: Med Oncol
Pays: United States
ID NLM: 9435512
Informations de publication
Date de publication:
14 Oct 2024
14 Oct 2024
Historique:
received:
25
06
2024
accepted:
09
08
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
14
10
2024
Statut:
epublish
Résumé
Extensive research supports an evidence-base for cancer treatment-related risk factors, including extent of lymph node dissection and use of radiotherapy, as contributing to secondary lymphedema. Additionally, comorbidities, such as higher body mass index, and vascular-related conditions are identified to further augment risk. While social determinants of health (SDOH) and socioeconomic factors are widely regarded as influencing an individual's healthcare outcomes, including cancer risk and survival, these factors have not been explored as risk factors for developing secondary lymphedema. A rapid literature review explored the current evidence for SDOH as risk factors for lymphedema. Studies that were published over the last 10 years and that specifically analyzed social factors as variables associated with lymphedema were included. Studies that only characterized the social determinants of the study population were not included. Forty-nine studies were identified through a rapid literature review, and 13 studies that expressly analyzed social determinants as risk factors for secondary lymphedema were reviewed and extracted. All studies were conducted in patients with breast cancer-related lymphedema. Social risk factors included race, educational level, insurance type, and income level. These are consistent with the socioeconomic inequalities related to cancer survival. SDOH may influence the risk of developing cancer treatment-related health conditions like secondary lymphedema. Research trials studying cancer treatment-related conditions should collect consistent and robust data across social, behavioral, environmental, and economic domains and should analyze these variables to understand their contribution to study endpoints. Risk prediction modeling could be a future pathway to better incorporate social determinants, along with medical and co-morbidity data, to holistically understand lymphedema risk.
Identifiants
pubmed: 39400761
doi: 10.1007/s12032-024-02474-7
pii: 10.1007/s12032-024-02474-7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
274Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Huang Z, Wu S. Acceptance of disability, coping style, perceived social support and quality of life among patients with chronic lymphedema: a cross-sectional study. Support Care Cancer. 2022;30(5):4099–108.
doi: 10.1007/s00520-022-06855-4
McDuff SG, Mina AI, Brunelle CL, et al. Timing of lymphedema after treatment for breast cancer: when are patients most at risk? Int J Radiat Oncol Biol Phys. 2019;103(1):62–70.
doi: 10.1016/j.ijrobp.2018.08.036
Yoshihara M, Shimono R, Tsuru S, et al. Risk factors for late-onset lower limb lymphedema after gynecological cancer treatment: a multi-institutional retrospective study. Eur J Surg Oncol. 2020;46(7):1334–8. https://doi.org/10.1016/j.ejso.2020.01.033 .
doi: 10.1016/j.ejso.2020.01.033
Bar AdV, Cheville A, Solin LJ, Dutta P, Both S, Harris EE. Time course of mild arm lymphedema after breast conservation treatment for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2010;76(1):85–90. https://doi.org/10.1016/j.ijrobp.2009.01.024 .
doi: 10.1016/j.ijrobp.2009.01.024
Gebruers N, Verbelen H, De Vrieze T, Coeck D, Tjalma W. Incidence and time path of lymphedema in sentinel node negative breast cancer patients: a systematic review. Arch Phys Med Rehabil. 2015;96(6):1131–9. https://doi.org/10.1016/j.apmr.2015.01.014 .
doi: 10.1016/j.apmr.2015.01.014
Stout NL, Binkley JM, Schmitz KH, et al. A prospective surveillance model for rehabilitation for women with breast cancer. Cancer. 2012;118(8 Suppl):2191–200. https://doi.org/10.1002/cncr.27476 .
doi: 10.1002/cncr.27476
McLaughlin SA, Stout NL, Schaverien MV. Avoiding the swell: advances in lymphedema prevention, detection, and management. Am Soc Clin Oncol Educ Book. 2020;40(40):1–10. https://doi.org/10.1200/EDBK_280471 .
doi: 10.1200/EDBK_280471
Hayes SC, Janda M, Cornish B, Battistutta D, Newman B. Lymphedema after breast cancer: incidence, risk factors, and effect on upper body function. J Clin Oncol. 2008;26(21):3536–42. https://doi.org/10.1200/JCO.2007.14.4899 .
doi: 10.1200/JCO.2007.14.4899
Kwan ML, Darbinian J, Schmitz KH, et al. Risk factors for lymphedema in a prospective breast cancer survivorship study: the pathways study. Arch Surg. 2010;145(11):1055–63. https://doi.org/10.1001/archsurg.2010.231 .
doi: 10.1001/archsurg.2010.231
pmcid: 2997775
Cormier JN, Askew RL, Mungovan KS, Xing Y, Ross MI, Armer JM. Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema. Cancer. 2010;116(22):5138–49. https://doi.org/10.1002/cncr.25458 .
doi: 10.1002/cncr.25458
Norman SA, Localio AR, Kallan MJ, et al. Risk factors for lymphedema after breast cancer treatment. Cancer Epidemiol Biomarkers Prev. 2010;19(11):2734–46. https://doi.org/10.1158/1055-9965.EPI-09-1245 .
doi: 10.1158/1055-9965.EPI-09-1245
pmcid: 2976830
Todo Y, Yamamoto R, Minobe S, et al. Risk factors for postoperative lower-extremity lymphedema in endometrial cancer survivors who had treatment including lymphadenectomy. Gynecol Oncol. 2010;119(1):60–4. https://doi.org/10.1016/j.ygyno.2010.06.018 .
doi: 10.1016/j.ygyno.2010.06.018
Paskett ED, Dean JA, Oliveri JM, Harrop JP. Cancer-related lymphedema risk factors, diagnosis, treatment, and impact: a review. J Clin Oncol. 2012;30(30):3726–33. https://doi.org/10.1200/JCO.2012.41.8574 .
doi: 10.1200/JCO.2012.41.8574
Akita S, Mitsukawa N, Rikihisa N, et al. Early diagnosis and risk factors for lymphedema following lymph node dissection for gynecologic cancer. Plast Reconstr Surg. 2013;131(2):283–90. https://doi.org/10.1097/PRS.0b013e318277870f .
doi: 10.1097/PRS.0b013e318277870f
Beesley VL, Rowlands IJ, Hayes SC, et al. Incidence, risk factors and estimates of a woman’s risk of developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in women treated for endometrial cancer. Gynecol Oncol. 2015;136(1):87–93.
doi: 10.1016/j.ygyno.2014.11.006
Shaitelman SF, Cromwell KD, Rasmussen JC, et al. Recent progress in the treatment and prevention of cancer-related lymphedema. CA Cancer J Clin. 2015;65(1):55–81. https://doi.org/10.3322/caac.21253 .
doi: 10.3322/caac.21253
Clinckaert A, Callens K, Cooreman A, et al. The prevalence of lower limb and genital lymphedema after prostate cancer treatment: a systematic review. Cancers (Basel). 2022. https://doi.org/10.3390/cancers14225667 .
doi: 10.3390/cancers14225667
Lin Y, Xu Y, Wang C, et al. Loco-regional therapy and the risk of breast cancer-related lymphedema: a systematic review and meta-analysis. Breast Cancer. 2021;28(6):1261–72. https://doi.org/10.1007/s12282-021-01263-8 .
doi: 10.1007/s12282-021-01263-8
Bona AF, Ferreira KR, Carvalho RBM, Thuler LCS, Bergmann A. Incidence, prevalence, and factors associated with lymphedema after treatment for cervical cancer: a systematic review. Int J Gynecol Cancer. 2020;30(11):1697–704. https://doi.org/10.1136/ijgc-2020-001682 .
doi: 10.1136/ijgc-2020-001682
Kuruvilla AS, Krajewski A, Li X, et al. Risk factors associated with postmastectomy breast cancer lymphedema: a multicenter retrospective analysis. Ann Plast Surg. 2022;88(3 Suppl 3):S239–45. https://doi.org/10.1097/sap.0000000000003107 .
doi: 10.1097/sap.0000000000003107
Ridner SH, Dietrich MS, Stewart BR, Armer JM. Body mass index and breast cancer treatment-related lymphedema. Support Care Cancer. 2011;19(6):853–7. https://doi.org/10.1007/s00520-011-1089-9 .
doi: 10.1007/s00520-011-1089-9
pmcid: 4480912
Rockson SG, Zhou X, Zhao L, et al. Exploring disease interrelationships in patients with lymphatic disorders: a single center retrospective experience. Clin Transl Med. 2022;12(4):e760.
doi: 10.1002/ctm2.760
pmcid: 9028099
Shahpar H, Atieh A, Maryam A, et al. Risk factors of lymph edema in breast cancer patients. Int J Breast Cancer. 2013. https://doi.org/10.1155/2013/641818 .
doi: 10.1155/2013/641818
pmcid: 3687507
Schmitz KH, Ahmed RL, Troxel AB, et al. Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial. JAMA. 2010;304(24):2699–705. https://doi.org/10.1001/jama.2010.1837 .
doi: 10.1001/jama.2010.1837
World Health Organization. Operational framework for monitoring social determinants of health equity. 2024. https://www.who.int/publications/i/item/9789240088320#:~:text=Download,(4.1%20MB) . Accessed 30 Mar 2024.
Centers for Disease Control and Prevention. About Social Determinants of Health (SDOH). https://www.cdc.gov/socialdeterminants/about.html . Accessed 15 Oct 2022.
Afshar N, English DR, Milne RL. Factors explaining socio-economic inequalities in cancer survival: a systematic review. Cancer Control. 2021;28:10732748211011956. https://doi.org/10.1177/10732748211011956 .
doi: 10.1177/10732748211011956
pmcid: 8204531
Gupta E, Mitchell CH, Ngo-Huang A, Manne R, Stout NL. Addressing social determinants of health to reduce disparities among individuals with cancer: insights for rehabilitation professionals. Curr Oncol Rep. 2023;25(6):659–69.
doi: 10.1007/s11912-023-01396-3
Badger TA, Segrin C, Crane TE, et al. Social determinants of health and symptom burden during cancer treatment. Nurs Res. 2023;72(2):103–13.
doi: 10.1097/NNR.0000000000000636
Brearley SG, Stamataki Z, Addington-Hall J, et al. The physical and practical problems experienced by cancer survivors: a rapid review and synthesis of the literature. Eur J Oncol Nurs. 2011;15(3):204–12. https://doi.org/10.1016/j.ejon.2011.02.005 .
doi: 10.1016/j.ejon.2011.02.005
Fettes L, Neo J, Ashford S, Higginson IJ, Maddocks M. Trajectories of disability in activities of daily living in advanced cancer or respiratory disease: a systematic review. Disabil Rehabil. 2022;44(10):1790–801.
doi: 10.1080/09638288.2020.1820587
Dean LT, Kumar A, Kim T, et al. Race or resource? BMI, race, and other social factors as risk factors for interlimb differences among overweight breast cancer survivors with lymphedema. J Obes. 2016;2016:8241710. https://doi.org/10.1155/2016/8241710 .
doi: 10.1155/2016/8241710
pmcid: 4940553
Haby MM, Chapman E, Clark R, Barreto J, Reveiz L, Lavis JN. What are the best methodologies for rapid reviews of the research evidence for evidence-informed decision making in health policy and practice: a rapid review. Health Res Policy Sys. 2016;14(1):83. https://doi.org/10.1186/s12961-016-0155-7 .
doi: 10.1186/s12961-016-0155-7
Stout NL, Brown JC, Schwartz AL, et al. An exercise oncology clinical pathway: screening and referral for personalized interventions. Cancer. 2020;126(12):2750–8. https://doi.org/10.1002/cncr.32860 .
doi: 10.1002/cncr.32860
Flores AM, Nelson J, Sowles L, et al. Lymphedema signs, symptoms, and diagnosis in women who are in minority and low-income groups and have survived breast cancer. Phys Ther. 2020;100(3):487–99. https://doi.org/10.1093/ptj/pzaa002 .
doi: 10.1093/ptj/pzaa002
pmcid: 7246063
Kwan ML, Yao S, Lee VS, et al. Race/ethnicity, genetic ancestry, and breast cancer-related lymphedema in the pathways study. Breast Cancer Res Treat. 2016;159(1):119–29. https://doi.org/10.1007/s10549-016-3913-x .
doi: 10.1007/s10549-016-3913-x
pmcid: 5010992
Montagna G, Zhang J, Sevilimedu V, et al. Risk factors and racial and ethnic disparities in patients with breast cancer-related lymphedema. JAMA Oncol. 2022;8(8):1195–200. https://doi.org/10.1001/jamaoncol.2022.1628 .
doi: 10.1001/jamaoncol.2022.1628
pmcid: 9185510
Nyrop KA, Damone EM, Deal AM, et al. Patient-reported treatment toxicity and adverse events in black and white women receiving chemotherapy for early breast cancer. Breast Cancer Res Treat. 2022;191(2):409–22. https://doi.org/10.1007/s10549-021-06439-6 .
doi: 10.1007/s10549-021-06439-6
Shakir A, Coalson E, Beederman M, Froimson JR, Chang DW. Health disparities in patients seeking physiological surgical treatment for lymphedema. Plast Reconstr Surg. 2023;151(1):217–24. https://doi.org/10.1097/prs.0000000000009761 .
doi: 10.1097/prs.0000000000009761
Rochlin DH, Barrio AV, McLaughlin S, et al. Feasibility and clinical utility of prediction models for breast cancer-related lymphedema incorporating racial differences in disease incidence. JAMA Surg. 2023;158(9):954–64. https://doi.org/10.1001/jamasurg.2023.2414 .
doi: 10.1001/jamasurg.2023.2414
pmcid: 10339225
Ren Y, Kebede MA, Ogunleye AA, et al. Burden of lymphedema in long-term breast cancer survivors by race and age. Cancer. 2022;128(23):4119–28. https://doi.org/10.1002/cncr.34489 .
doi: 10.1002/cncr.34489
Togawa K, Ma H, Sullivan-Halley J, et al. Risk factors for self-reported arm lymphedema among female breast cancer survivors: a prospective cohort study. Breast Cancer Res. 2014;16(4):414. https://doi.org/10.1186/s13058-014-0414-x .
doi: 10.1186/s13058-014-0414-x
pmcid: 4189147
Sayan M, Kilic SS, Vergalasova I, et al. Risk factors for the development of clinical and subclinical lymphedema detected by bioimpedance spectroscopy. Clin Breast Cancer. 2022;22(6):553–9. https://doi.org/10.1016/j.clbc.2022.04.003 .
doi: 10.1016/j.clbc.2022.04.003
Shen A, Lu Q, Fu X, et al. Risk factors of unilateral breast cancer-related lymphedema: an updated systematic review and meta-analysis of 84 cohort studies. Support Care Cancer. 2022;31(1):18. https://doi.org/10.1007/s00520-022-07508-2 .
doi: 10.1007/s00520-022-07508-2
Koelmeyer LA, Borotkanics RJ, Alcorso J, et al. Early surveillance is associated with less incidence and severity of breast cancer-related lymphedema compared with a traditional referral model of care. Cancer. 2019;125(6):854–62. https://doi.org/10.1002/cncr.31873 .
doi: 10.1002/cncr.31873
Stout Gergich NL, Pfalzer LA, McGarvey C, Springer B, Gerber LH, Soballe P. Preoperative assessment enables the early diagnosis and successful treatment of lymphedema. Cancer. 2008;112(12):2809–19. https://doi.org/10.1002/cncr.23494 .
doi: 10.1002/cncr.23494
Morehead-Gee AJ, Pfalzer L, Levy E, et al. Racial disparities in physical and functional domains in women with breast cancer. Support Care Cancer. 2012;20(8):1839–47. https://doi.org/10.1007/s00520-011-1285-7 .
doi: 10.1007/s00520-011-1285-7
Deng J, Ridner SH, Dietrich MS, et al. Factors associated with external and internal lymphedema in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2012;84(3):e319–28. https://doi.org/10.1016/j.ijrobp.2012.04.013 .
doi: 10.1016/j.ijrobp.2012.04.013
Meeske KA, Sullivan-Halley J, Smith AW, et al. Risk factors for arm lymphedema following breast cancer diagnosis in black women and white women. Breast Cancer Res Treat. 2009;113:383–91.
doi: 10.1007/s10549-008-9940-5
Ding JF. Prospective surveillance and risk reduction of cancer treatment-related lymphedema: systematic review and meta-analysis. Oncol Nurs Forum. 2020;47(5):E161–70.
doi: 10.1188/20.ONF.E161-E170
Karaca-Mandic P, Solid CA, Armer JM, Skoracki R, Campione E, Rockson SG. Lymphedema self-care: economic cost savings and opportunities to improve adherence. Cost Eff Resour Alloc. 2023;21(1):47.
doi: 10.1186/s12962-023-00455-7
pmcid: 10386258
Koroukian SM, Dong W, Albert JM, et al. Treatment patterns and survival outcomes in patients with breast cancer on medicaid, pre- and post-expansion. J Natl Compr Canc Netw. 2024. https://doi.org/10.6004/jnccn.2023.7104 .
doi: 10.6004/jnccn.2023.7104
Byun M, Kim E, Ahn H. Factors contributing to poor self-rated health in older adults with lower income. Healthcare (Basel). 2021. https://doi.org/10.3390/healthcare9111515 .
doi: 10.3390/healthcare9111515
pmcid: 8512453
Papageorge MV, Woods AP, de Geus SW, et al. The persistence of poverty and its impact on cancer diagnosis, treatment and survival. Ann Surg. 2023;277(6):995–1001.
doi: 10.1097/SLA.0000000000005455
Boscoe FP, Henry KA, Sherman RL, Johnson CJ. The relationship between cancer incidence, stage and poverty in the United States. Int J Cancer. 2016;139(3):607–12.
doi: 10.1002/ijc.30087
Bian J, Shen A, Yang W, Zhang L, Qiang W. Financial toxicity experienced by patients with breast cancer-related lymphedema: a systematic review. Support Care Cancer. 2023;31(6):354.
doi: 10.1007/s00520-023-07800-9
Dean LT, Moss SL, Ransome Y, et al. “It still affects our economic situation”: long-term economic burden of breast cancer and lymphedema. Support Care Cancer. 2019;27:1697–708.
doi: 10.1007/s00520-018-4418-4
Boyages J, Xu Y, Kalfa S, et al. Financial cost of lymphedema borne by women with breast cancer. Psychooncology. 2017;26(6):849–55.
doi: 10.1002/pon.4239
Unger JM, Moseley A, Symington B, Chavez-MacGregor M, Ramsey SD, Hershman DL. Geographic distribution and survival outcomes for rural patients with cancer treated in clinical trials. JAMA Netw Open. 2018;1(4):181235. https://doi.org/10.1001/jamanetworkopen.2018.1235 .
doi: 10.1001/jamanetworkopen.2018.1235
Xu Y, Fu C, Onega T, Shi X, Wang F. Disparities in geographic accessibility of national cancer institute cancer centers in the United States. J Med Syst. 2017;41(12):203. https://doi.org/10.1007/s10916-017-0850-0 .
doi: 10.1007/s10916-017-0850-0
pmcid: 8208496
Lee EK, Donley G, Ciesielski TH, et al. Health outcomes in redlined versus non-redlined neighborhoods: a systematic review and meta-analysis. Soc Sci Med. 2022;294:114696. https://doi.org/10.1016/j.socscimed.2021.114696 .
doi: 10.1016/j.socscimed.2021.114696
Hong Y-R, Wang R, Case S, Jo A, Turner K, Ross KM. Association of food insecurity with overall and disease-specific mortality among cancer survivors in the US. Support Care Cancer. 2024;32(5):309.
doi: 10.1007/s00520-024-08495-2
Parks CA, Carpenter LR, Sullivan KR, et al. A scoping review of food insecurity and related factors among cancer survivors. Nutrients. 2022;14(13):2723.
doi: 10.3390/nu14132723
pmcid: 9269347
Zahnd WE, McLafferty SL. Contextual effects and cancer outcomes in the United States: a systematic review of characteristics in multilevel analyses. Ann Epidemiol. 2017;27(11):739-48.e3. https://doi.org/10.1016/j.annepidem.2017.10.002 .
doi: 10.1016/j.annepidem.2017.10.002
Alcaraz KI, Wiedt TL, Daniels EC, Yabroff KR, Guerra CE, Wender RC. Understanding and addressing social determinants to advance cancer health equity in the United States: a blueprint for practice, research, and policy. CA Cancer J Clin. 2020;70(1):31–46.
doi: 10.3322/caac.21586
Warnecke RB, Oh A, Breen N, et al. Approaching health disparities from a population perspective: the national institutes of health centers for population health and health disparities. Am J Public Health. 2008;98(9):1608–15. https://doi.org/10.2105/ajph.2006.102525 .
doi: 10.2105/ajph.2006.102525
pmcid: 2509592
Lynch S, Street NW, Sharpe L, Kellish A. Social determinants of health screening: primary care PRAPARE tool implementation. J Nurse Pract. 2024;20(4):104955.
doi: 10.1016/j.nurpra.2024.104955
Tesfaye S, Cronin RM, Lopez-Class M, et al. Measuring social determinants of health in the All of Us research program. Sci Rep. 2024;14(1):8815.
doi: 10.1038/s41598-024-57410-6
pmcid: 11021514
Andermann A. Screening for social determinants of health in clinical care: moving from the margins to the mainstream. Public Health Rev. 2018;39(1):19. https://doi.org/10.1186/s40985-018-0094-7 .
doi: 10.1186/s40985-018-0094-7
pmcid: 6014006
Guidi J, Lucente M, Sonino N, Fava GA. Allostatic load and its impact on health: a systematic review. Psychother Psychosom. 2020;90(1):11–27. https://doi.org/10.1159/000510696 .
doi: 10.1159/000510696
Obeng-Gyasi S, Elsaid MI, Lu Y, et al. Association of allostatic load with all-cause mortality in patients with breast cancer. JAMA Netw Open. 2023;6(5):e2313989.
doi: 10.1001/jamanetworkopen.2023.13989
pmcid: 10196875
Obeng-Gyasi S, Graham N, Kumar S, et al. Examining allostatic load, neighborhood socioeconomic status, symptom burden and mortality in multiple myeloma patients. Blood Cancer J. 2022;12(4):53.
doi: 10.1038/s41408-022-00648-y
pmcid: 8975964
Chen J, Elsaid MI, Handley D, et al. Allostatic load as a predictor of postoperative complications in patients with breast cancer. NPJ Breast Cancer. 2024;10(1):44.
doi: 10.1038/s41523-024-00654-2
pmcid: 11169387