Vitrectomy in Small idiopathic MAcuLar hoLe (SMALL) study: Internal limiting membrane peeling versus no peeling.
closure rate
macular hole
no‐peeling
optical coherence tomography
peeling
small
visual acuity
vitrectomy
vitreomacular traction
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
14 Oct 2024
14 Oct 2024
Historique:
received:
25
07
2024
accepted:
03
10
2024
medline:
14
10
2024
pubmed:
14
10
2024
entrez:
14
10
2024
Statut:
aheadofprint
Résumé
To compare vitrectomy with and without internal limiting membrane (ILM) peeling in small idiopathic macular holes. Retrospective multicentre study including consecutive eyes with ≤250 μm idiopathic macular hole treated with vitrectomy. The primary outcome was hole closure rate. Best-corrected visual acuity (BCVA) change, closure patterns on optical coherence tomography, rates of external limiting membrane (ELM) and ellipsoid zone (EZ) recovery, and rate of complications were also investigated. In total, 693 eyes were included. Hole closure rate was 98% in the peeling and 85% in the no-peeling group (p < 0.001). At 12 months, mean BCVA change was 0.38 ± 0.22 logMAR in the peeling and 0.45 ± 0.21 logMAR in the no-peeling group (p = 0.02); 66% versus 80% of eyes had a U-shaped morphology, respectively; EZ recovery rate was 75% and 93%, respectively (p = 0.02). In the no-peeling group, eyes with a vitreomacular traction (VMT) showed a 96% closure rate, comparable to the peeling group (p = 0.40). The incidence of adverse events was similar except for dissociated optic nerve fibre layer (55% in the peeling vs. 9% in the no-peeling group, p < 0.001). In small idiopathic macular holes, ILM peeling provides a higher closure rate compared to no-peeling; however, if a VMT is present closure rates are comparable. In closed macular holes, the no-peeling technique provides advantages in terms of visual outcome and anatomical recovery.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Tommaso Micelli Ferrari
(TM)
Massimo Lorusso
(M)
Vito Primavera
(V)
Gianluigi Giuliani
(G)
Cesare Mariotti
(C)
Marco Lupidi
(M)
Luca Ventre
(L)
Giulia Pintore
(G)
Lorenzo Motta
(L)
Matteo Ripa
(M)
Francesco Boscia
(F)
Giacomo Boscia
(G)
Mario R Romano
(MR)
Mariantonia Ferrara
(M)
Kacerik Miroslav
(K)
Daniele Marchina
(D)
Barbara Parolini
(B)
Enrico Peiretti
(E)
Viola Marchiori
(V)
Roberto Dell'Omo
(R)
Marzia Affatato
(M)
Teresio Avitabile
(T)
Andrea Russo
(A)
Antonio Longo
(A)
Vincenzo Scorcia
(V)
Adriano Carnevali
(A)
Rodolfo Mastropasqua
(R)
Lisa Toto
(L)
Agostino Salvatore Vaiano
(AS)
Riccardo Merli
(R)
Marco Mura
(M)
Marco Pellegrini
(M)
Fabrizio Giansanti
(F)
Cristina Nicolosi
(C)
Matteo Badino
(M)
Nicola Pallozzi Lavorante
(NP)
Maria T Sandinha
(MT)
Francesco Maria D'Alterio
(FM)
Mario Damiano Toro
(MD)
Robert Rejdak
(R)
Paolo Chelazzi
(P)
Claudia Azzolini
(C)
Francesco Viola
(F)
Caterina Donà
(C)
Matteo Giuseppe Cereda
(MG)
Marco Casaluci
(M)
Marco Codenotti
(M)
Lorenzo Iuliano
(L)
Grazia Pertile
(G)
Daniele Sindaco
(D)
Stefano De Cillà
(S)
Andrea Muraca
(A)
Vincenza M E Bonfiglio
(VME)
Maria Vadalà
(M)
Alberto La Mantia
(A)
Viviana Randazzo
(V)
Tito Fiore
(T)
Gianluigi Tosi
(G)
Rino Frisina
(R)
Chiara Angeli
(C)
Marco Coassin
(M)
Mariateresa Laborante
(M)
Tommaso Rossi
(T)
Pamela Cosimi
(P)
Stanislao Rizzo
(S)
Matteo Mario Carlà
(MM)
Magda Gharbiya
(M)
Giuseppe Maria Albanese
(GM)
Luigi Caretti
(L)
Edoardo Angelini
(E)
Gian Marco Tosi
(GM)
Tommaso Bacci
(T)
David H Steel
(DH)
Nikolaos Dervenis
(N)
Iordanis Vagiakis
(I)
Daniele Tognetto
(D)
Marco Rocco Pastore
(MR)
Francesco Faraldi
(F)
Carlo Alessandro Lavia
(CA)
Paolo Lanzetta
(P)
Daniele Veritti
(D)
Leopoldo Rubinato
(L)
Paolo Radice
(P)
Andrea Govetto
(A)
Informations de copyright
© 2024 The Author(s). Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
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