Neurodevelopmental predictors of treatment response in schizophrenia and bipolar disorder.
age at onset of disease
bipolar disorder
neurodevelopment
neurological soft signs
schizophrenia
treatment response
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
15 Oct 2024
15 Oct 2024
Historique:
medline:
15
10
2024
pubmed:
15
10
2024
entrez:
15
10
2024
Statut:
aheadofprint
Résumé
Treatment resistance is a major challenge in psychiatric disorders. Early detection of potential future resistance would improve prognosis by reducing the delay to appropriate treatment adjustment and recovery. Here, we sought to determine whether neurodevelopmental markers can predict therapeutic response. Healthy controls ( Developmental abnormalities were more frequent in schizophrenia and bipolar disorder than in controls. NSS significantly differed between controls, responsive, and resistant participants with schizophrenia (5.5 ± 3.0, 7.0 ± 4.0, 15.0 ± 6.0 respectively, Neurodevelopmental features such as NSS and age of clinical onset provide a means to identify patients who may require rapid treatment adaptation.
Sections du résumé
BACKGROUND
BACKGROUND
Treatment resistance is a major challenge in psychiatric disorders. Early detection of potential future resistance would improve prognosis by reducing the delay to appropriate treatment adjustment and recovery. Here, we sought to determine whether neurodevelopmental markers can predict therapeutic response.
METHODS
METHODS
Healthy controls (
RESULTS
RESULTS
Developmental abnormalities were more frequent in schizophrenia and bipolar disorder than in controls. NSS significantly differed between controls, responsive, and resistant participants with schizophrenia (5.5 ± 3.0, 7.0 ± 4.0, 15.0 ± 6.0 respectively,
CONCLUSIONS
CONCLUSIONS
Neurodevelopmental features such as NSS and age of clinical onset provide a means to identify patients who may require rapid treatment adaptation.
Identifiants
pubmed: 39402801
doi: 10.1017/S0033291724001776
pii: S0033291724001776
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-12Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-19-CHIA-0010-01 "Big2Small"
Organisme : HORIZON EUROPE Framework Programme
ID : H2020-SC1-2017, 754907