Leukotriene B4 is elevated in diabetes and promotes ventricular arrhythmogenesis in guinea pig.

IKr diabetes guinea pig hERG leukotriene B4 ventricular arrhythmias

Journal

Journal of cellular physiology

ISSN: 1097-4652

Titre abrégé: J Cell Physiol

Pays: United States

ID NLM: 0050222

Informations de publication

Date de publication:
14 Oct 2024

Historique:

revised: 15 09 2024

received: 03 07 2024

accepted: 01 10 2024

medline: 15 10 2024

pubmed: 15 10 2024

entrez: 15 10 2024

Statut: aheadofprint

Résumé

Diabetes (DM) patients have an increased risk (~50%) for sudden cardiac death (SCD), mostly as a result of ventricular arrhythmias. The molecular mechanisms involved remain partially defined. The potent proinflammatory lipid mediator leukotriene (LT) B4, is pathologically elevated in DM compared to nondiabetic patients, resulting in increased LTB4 accumulation in heart, leading to an increased risk for life-threatening proarrhythmic signatures. We used electrophysiology, immunofluorescence, and confocal microscopy approaches to evaluate LTB4 cellular effects in guinea pig heart and ventricular myocytes. We have observed that LTB4 is increased in multiple mouse models (C57BL/6 J/Lep

Identifiants

DOI: 10.1002/jcp.31467 PMID: 39402808

pubmed: 39402808

doi: 10.1002/jcp.31467

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

e31467

Subventions

Organisme : NHLBI NIH HHS

ID : R01 HL147044-01

Pays : United States

Organisme : NHLBI NIH HHS

ID : R01 HL174450-01

Pays : United States

Informations de copyright

Références

Balkau, B., Jouven, X., Ducimetière, P., & Eschwège, E. (1999). Diabetes as a risk factor for sudden death. The Lancet, 354(9194), 1968–1969. https://doi.org/10.1016/S0140-6736(99)04383-4

Bukiya, A. N., McMillan, J., Liu, J., Shivakumar, B., Parrill, A. L., & Dopico, A. M. (2015). Direct modulation of calcium‐ and voltage‐gated potassium channels of large conductance by leukotrienes. Biophysical Journal, 108(2), 280a. https://doi.org/10.1016/j.bpj.2014.11.1531

Chowdhury, M. K. H., Martinez‐Mateu, L., Do, J., Aromolaran, K. A., Saiz, J., & Aromolaran, A. S. (2021). Macrophage‐dependent interleukin‐6‐production and inhibition of I(K) contributes to acquired QT prolongation in lipotoxic Guinea pig heart. International Journal of Molecular Sciences, 22(20), 11249. https://doi.org/10.3390/ijms222011249

Corbin, A., Aromolaran, K. A., & Aromolaran, A. S. (2024). STAT4 mediates IL‐6 trans‐signaling ventricular arrhythmias in high fat diet Guinea pig heart. International Journal of Molecular Sciences, 25(14), 7813.

DeFronzo, R. A. (2004). Pathogenesis of type 2 diabetes mellitus. Medical Clinics of North America, 88(4), 787–835. https://doi.org/10.1016/j.mcna.2004.04.013

Ehrhardt‐Humbert, L., & Singleton, M. J. (2023). Physiologic Measures in Diabetes: QTc Prolongation. In V. B. Patel & V. R. Preedy (Eds.), Biomarkers in Diabetes (pp. 809–820). Springer International Publishing.

Garrido, A., Lepailleur, A., Mignani, S. M., Dallemagne, P., & Rochais, C. (2020). hERG toxicity assessment: Useful guidelines for drug design. European Journal of Medicinal Chemistry, 195, 112290. https://doi.org/10.1016/j.ejmech.2020.112290

Gonca, E. (2013). The effects of zileuton and montelukast in reperfusion‐induced arrhythmias in anesthetized rats. Current Therapeutic Research, 75, 27–32. https://doi.org/10.1016/j.curtheres.2013.06.001

Hegyi, B., Bers, D. M., & Bossuyt, J. (2019). CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 127, 246–259. https://doi.org/10.1016/j.yjmcc.2019.01.001

Huang, X., Liu, G., Guo, J., & Su, Z. (2018). The PI3K/AKT pathway in obesity and type 2 diabetes. International Journal of Biological Sciences, 14(11), 1483–1496. https://doi.org/10.7150/ijbs.27173

Li, P., Oh, D. Y., Bandyopadhyay, G., Lagakos, W. S., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., Ofrecio, J. M., Taguchi, S., Lu, M., & Olefsky, J. M. (2015). LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nature Medicine, 21(3), 239–247. https://doi.org/10.1038/nm.3800

Light, P. E. (2021). Decoding the effects of SGLT2 inhibitors on cardiac arrhythmias in heart failure. European Heart Journal, 42(36), 3739–3740. https://doi.org/10.1093/eurheartj/ehab563

Liu, X., Yang, T., Miao, L., Mei, Y. A., & Hu, C. (2015). Leukotriene B4 inhibits L‐Type calcium channels via p38 signaling pathway in vascular smooth muscle cells. Cellular Physiology and Biochemistry, 37(5), 1903–1913. https://doi.org/10.1159/000438551

Mastalerz, L., & Kumik, J. (2010). Antileukotriene drugs in the treatment of asthma. Polish Archives of Internal Medicine, 120(3), 103–108.

Oh, D. Y., & Olefsky, J. M. (2016). G protein‐coupled receptors as targets for anti‐diabetic therapeutics. Nature Reviews Drug Discovery, 15(3), 161–172. https://doi.org/10.1038/nrd.2015.4

Puckerin, A., Aromolaran, K. A., Chang, D. D., Zukin, R. S., Colecraft, H. M., Boutjdir, M., & Aromolaran, A. S. (2016). hERG 1a LQT2 C‐terminus truncation mutants display hERG 1b‐dependent dominant negative mechanisms. Heart rhythm: the official journal of the Heart Rhythm Society, 13(5), 1121–1130. https://doi.org/10.1016/j.hrthm.2016.01.012

Quagliariello, V., De Laurentiis, M., Rea, D., Barbieri, A., Monti, M. G., Carbone, A., Paccone, A., Altucci, L., Conte, M., Canale, M. L., Botti, G., & Maurea, N. (2021). The SGLT‐2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro‐inflammatory cytokines in non‐diabetic mice treated with doxorubicin. Cardiovascular Diabetology, 20(1), 150. https://doi.org/10.1186/s12933-021-01346-y

Rawshani, A., McGuire, D. K., Omerovic, E., Sattar, N., McMurray, J. J. V., Smith, U., Redfors, B., Bergfeldt, L., Eliasson, B., Borén, J., Bhatt, D. L., Bergstrom, G., & Rawshani, A. (2023). Cardiac arrhythmias and conduction abnormalities in patients with type 2 diabetes. Scientific Reports, 13(1), 1192. https://doi.org/10.1038/s41598-023-27941-5

Reddy, S., Bose, R., Rao, G. H., & Murthy, M. (1995). Phospholipase A2 activation in human neutrophils requires influx of extracellular Ca2+ and leukotriene B4. American Journal of Physiology‐Cell Physiology, 268(1 Pt 1), C138–C146. https://doi.org/10.1152/ajpcell.1995.268.1.C138

Ritchie, R. H., Zerenturk, E. J., Prakoso, D., & Calkin, A. C. (2017). Lipid metabolism and its implications for type 1 diabetes‐associated cardiomyopathy. Journal of Molecular Endocrinology, 58(4), R225–R240. https://doi.org/10.1530/jme-16-0249

Rola‐Pleszczynski, M., & Stankova, J. (2007). Cytokine‐leukotriene receptor interactions. The Scientific World Journal, 7, 1348–1358. https://doi.org/10.1100/tsw.2007.183

Tager, A. M., & Luster, A. D. (2003). BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins, Leukotrienes and Essential Fatty Acids, 69(2–3), 123–134. https://doi.org/10.1016/s0952-3278(03)00073-5

Uppal, P., Mohammed, S. A., Rajashekar, S., Giri Ravindran, S., Kakarla, M., Ausaja Gambo, M., Yousri Salama, M., Haidar Ismail, N., Tavalla, P., & Hamid, P. (2023). Type 2 diabetes mellitus and asthma: pathomechanisms of their association and clinical implications. Cureus, 15(3), e36047. https://doi.org/10.7759/cureus.36047

Wang, M.‐Y., Dean, E. D., Quittner‐Strom, E., Zhu, Y., Chowdhury, K. H., Zhang, Z., Zhao, S., Li, N., Ye, R., Lee, Y., Zhang, Y., Chen, S., Yu, X., Leonard, D. C., Poffenberger, G., Von Deylen, A., McCorkle, S. K., Schlegel, A., Sloop, K. W., … Holland, W. L. (2021). Glucagon blockade restores functional β‐cell mass in type 1 diabetic mice and enhances function of human islets. Proceedings of the National Academy of Sciences of the United States of America, 118(9), e2022142118. https://doi.org/10.1073/pnas.2022142118

Wang, Z. V., Mu, J., Schraw, T. D., Gautron, L., Elmquist, J. K., Zhang, B. B., Brownlee, M., & Scherer, P. E. (2008). PANIC‐ATTAC: A mouse model for inducible and reversible β‐Cell ablation. Diabetes, 57(8), 2137–2148. https://doi.org/10.2337/db07-1631

Watanabe, E., Tanabe, T., Osaka, M., Chishaki, A., Takase, B., Niwano, S., Watanabe, I., Sugi, K., Katoh, T., Takayanagi, K., Mawatari, K., Horie, M., Okumura, K., Inoue, H., Atarashi, H., Yamaguchi, I., Nagasawa, S., Moroe, K., Kodama, I., … Aizawa, Y. (2014). Sudden cardiac arrest recorded during Holter monitoring: Prevalence, antecedent electrical events, and outcomes. Heart rhythm: the official journal of the Heart Rhythm Society, 11(8), 1418–1425. https://doi.org/10.1016/j.hrthm.2014.04.036

Williams, F. M. (1996). Neutrophils and myocardial reperfusion injury. Pharmacology & Therapeutics, 72(1), 1–12. https://doi.org/10.1016/S0163-7258(96)00090-3

Williams, R., Karuranga, S., Malanda, B., Saeedi, P., Basit, A., Besançon, S., Bommer, C., Esteghamati, A., Ogurtsova, K., Zhang, P., & Colagiuri, S. (2020). Global and regional estimates and projections of diabetes‐related health expenditure: Results from the international diabetes federation diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice, 162, 108072. https://doi.org/10.1016/j.diabres.2020.108072

Xu, G., Liu, B., Sun, Y., Du, Y., Snetselaar, L. G., Hu, F. B., & Bao, W. (2018). Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: Population based study. BMJ (Clinical research ed.), 362, k1497. https://doi.org/10.1136/bmj.k1497

Zeng, J., Laurita, K. R., Rosenbaum, D. S., & Rudy, Y. (1995). Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization. Circulation Research, 77(1), 140–152. https://doi.org/10.1161/01.res.77.1.140